Primary Information |
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| BoMiProt ID | Bomi6315 |
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| Protein Name | Homeobox protein MSX-1/Msh homeobox 1-like protein |
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| Organism | Bos taurus |
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| Uniprot ID | O02786 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777223.1 |
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| Aminoacid Length | 303 |
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| Molecular Weight | 31668 |
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| FASTA Sequence |
Download |
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| Gene Name | MSX1 |
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| Gene ID | 286872 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | transcriptional repressor inhibits BMP 2 and BMP 4 and lymphoid enhancer-binding factor 1 via Wnt/β-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Participate in limb-pattern formation and tooth formation. |
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| PTMs | Isopeptide bond formation, Ubl conjugation,SUMOylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1 long disordered segment; (2-179) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Suppression of the transcription factor MSX1 gene delays bovine preimplantation embryo development in vitro |
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| Bibliography | Feng XY, Wu XS, Wang JS, Zhang CM, Wang SL. Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/β-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12. doi: 10.1111/eos.12390. Epub 2017 Nov 17. PMID: 29148101. |
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