Search by BoMiProt ID - Bomi6311

Primary Information

BoMiProt ID Bomi6311
Protein Name Homeobox protein Hox-A2
Organism Bos taurus
Uniprot IDQ0VCS4
Milk FractionWhey
Ref Sequence ID NP_001069322.1
Aminoacid Length 372
Molecular Weight 40840
FASTA Sequence Download
Gene Name HOXA2
Gene ID 524150
Protein Existence Status reviewed

Secondary Information

Protein Function  involved in hindbrain and cranio-facial development during mammalian embryogenesis,Hoxa2 controls development in alar and 'dorsal' basal plates of r2 and r3.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 3-143, 198-279, 287-349
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs PPP1CB and KPC2 decreases ubiqinated form of HOXA2 and maintain its stability.
Bibliography Deneyer N, Bridoux L, Bombled C, Pringels T, Bergiers I, Pyr Dit Ruys S, Vertommen D, Twizere JC, Rezsohazy R. HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification. Biochim Biophys Acta Gene Regul Mech. 2019 Sep;1862(9):194404. doi: 10.1016/j.bbagrm.2019.07.005. Epub 2019 Jul 16. PMID: 31323436.