|Protein Name||Heat shock protein HSP 90-alpha|
|Milk Fraction||Whey, MFGM, Exosome|
|Ref Sequence ID||NP_001012688.1|
|Protein Existence Status||Reviewed: Experimental evidence at protein level|
|Protein Function||regulates efficient transport of peptides from the proteasome to MHC1; bind ATP; molecular chaperone normal unstressed cells; role in modifying antigen presentation; glial-axon transfer proteins; interact directly with fatty acids - interaction may be part of their mode of binding to cell membranes; resist noxious stimuli both in vitro and in vivo; ubiquitous expression of hsp70, hsp90, calreticulin and gp96 in cells essentially ensures that the MHC I presentation pathway remains functional in all nucleated cells; Hsp70 and hsp90 form heteromultimeric complexes in the cytosol with other co-chaperones; Hsp90 and hsp70 are intimately involved in the extrusion of antigens from the endosomes to the cytosol through a putative pore structure;protection of human monocytes from hydrogen peroxideinduced toxicity; guinea pig gastric mucosal cells from ethanol damage|
|Biochemical Properties||cytosolic HSP; Hsp90 has been shown to physically associate with the proteasome, and in certain instances replace the PA28 subunits; inhibitor is 17-AAG|
|Significance in milk||heat stress proteins in mamary gland|
| Site(s) of PTM(s) |
|Predicted Disorder Regions||225-279,700-733|
|TM Helix Prediction||No TM helices|
|Significance of PTMs||sensitive to heat stress and mainly responsible for mammary cell protection from heat stress|
|Bibliography||1. Ichiyanagi, T., Imai, T., Kajiwara, C., Mizukami, S., Nakai, A., Nakayama, T., & Udono, H. (2010). Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. Journal of Immunology (Baltimore, Md. : 1950), 185(5), 2693–2700. https://doi.org/10.4049/jimmunol.1000821. |
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4. Samali, A., & Cotter, T. G. (1996). Heat shock proteins increase resistance to apoptosis. Experimental Cell Research, 223(1), 163–170. https://doi.org/10.1006/excr.1996.0070.
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6. Shi, Y., & Thomas, J. O. (1992). The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate. Molecular and Cellular Biology, 12(5), 2186–2192. https://doi.org/10.1128/mcb.12.5.2186.
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