Search by BoMiProt ID - Bomi6285


Primary Information

BoMiProt ID Bomi6285
Protein Name Histone H2A type 1/H2A.1b
Organism Bos taurus
Uniprot IDP0C0S9
Milk FractionWhey
Ref Sequence ID NP_001092190.1
Aminoacid Length 130
Molecular Weight 14091
FASTA Sequence Download
Gene Name N/A
Gene ID 104968446 104975683 529277 616790 618824
Protein Existence Status reviewed

Secondary Information

Protein Function Core component of nucleosome.
Biochemical Properties N terminal and C terminal tail which undergoes PTM
PTMs Acetylation, Citrullination, Hydroxylation, Isopeptide bond formation, Methylation, Phosphorylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P0C0S9|H2A1_BOVIN Histone H2A type 1 OS=Bos taurus OX=9913 PE=1 SV=2 MS*2GRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK T*121ESHHKAKGK
CATH Matched CATH superfamily
n/a
Predicted Disorder Regions 1-32, 115-130
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.
PDB ID 6FML,