Primary Information | |
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BoMiProt ID | Bomi6285 |
Protein Name | Histone H2A type 1/H2A.1b |
Organism | Bos taurus |
Uniprot ID | P0C0S9 |
Milk Fraction | Whey |
Ref Sequence ID | NP_001092190.1 |
Aminoacid Length | 130 |
Molecular Weight | 14091 |
FASTA Sequence | Download |
Gene Name | N/A |
Gene ID | 104968446 104975683 529277 616790 618824 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | Core component of nucleosome. |
Biochemical Properties | N terminal and C terminal tail which undergoes PTM |
PTMs | Acetylation, Citrullination, Hydroxylation, Isopeptide bond formation, Methylation, Phosphorylation, Ubl conjugation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P0C0S9|H2A1_BOVIN Histone H2A type 1 OS=Bos taurus OX=9913 PE=1 SV=2 MS*2GRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK T*121ESHHKAKGK |
CATH | Matched CATH superfamily n/a |
Predicted Disorder Regions | 1-32, 115-130 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
Significance of PTMs | Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. |
PDB ID | 6FML, |