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Primary Information | |
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| BoMiProt ID | Bomi6285 |
| Protein Name | Histone H2A type 1/H2A.1b |
| Organism | Bos taurus |
| Uniprot ID | P0C0S9 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001092190.1 |
| Aminoacid Length | 130 |
| Molecular Weight | 14091 |
| FASTA Sequence | Download |
| Gene Name | N/A |
| Gene ID | 104968446 104975683 529277 616790 618824 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Core component of nucleosome. |
| Biochemical Properties | N terminal and C terminal tail which undergoes PTM |
| PTMs | Acetylation, Citrullination, Hydroxylation, Isopeptide bond formation, Methylation, Phosphorylation, Ubl conjugation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P0C0S9|H2A1_BOVIN Histone H2A type 1 OS=Bos taurus OX=9913 PE=1 SV=2 MS*2GRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK T*121ESHHKAKGK |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | 1-32, 115-130 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. |
| PDB ID | 6FML, |