Primary Information |
|---|
| BoMiProt ID | Bomi6279 |
|---|
| Protein Name | Histone H1.1/Histone H1a |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | G3N131 |
|---|
| Milk Fraction | Whey,Casein |
|---|
| Ref Sequence ID | XP_010816821.1 |
|---|
| Aminoacid Length | 218 |
|---|
| Molecular Weight | 22100 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | H1-1/HIST1H1A |
|---|
| Gene ID | 618164 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | Participate in chromatin condensation.H1 histones bind to linker DNA between nucleosomes |
|---|
| PTMs | Acetylation, Citrullination, Hydroxylation, Phosphoprotein |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|G3N131|H11_BOVIN Histone H1.1 OS=Bos taurus OX=9913 GN=H1-1 PE=1 SV=1
MS*2EVALPAPAAS*12TSPEKPSAGKKAKKPAKAAAAAKKKPAGPSVS*44ELIVQAVSSSKERSGV
SLAALKKALAAAGYDVEKNNSRIKLGLKSLVGKGTLVQTKGTGASGS*107FKLNKKVASVDAK
PTATKVATKTKVTSASKKPKKASGAAAAKKSVKTPKKARKSVLTKKSSKSPKKPKAVKPK
KVAKSPAKAKAVKPKGAKVKVTKPKT*206AAKPKKAAPKKK |
|---|
| Predicted Disorder Regions | (1-218) |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.Citrullination of a single arginine residue within the DNA-binding site of H1 results in its displacement from chromatin and global chromatin decondensation. |
|---|
| Bibliography | Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T. Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 2014 Mar 6;507(7490):104-8. doi: 10.1038/nature12942. Epub 2014 Jan 26. PMID: 24463520; PMCID: PMC4843970. |
|---|
