Search by BoMiProt ID - Bomi6263

Primary Information

BoMiProt ID Bomi6263
Protein Name Histatherin
Organism Bos taurus
Uniprot IDC6KGD8
Milk FractionWhey
Ref Sequence ID NP_001156886.1
Aminoacid Length 58
Molecular Weight 7233
FASTA Sequence Download
Gene Name HSTN
Gene ID 100302500
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells mammary glands
Protein Function Antimicrobial activity..Histatherin is a small 6 kDa chimera of a protein called Statherin and group of proteins called Histatins. cationic proteins which are involved in innate immunity. Statherin, which is also small and cationic in structure, is responsible for the super-saturation of calcium in saliva and protection of tooth enamel 
Biochemical Properties Amino acid analysis revealed that the similarity of bovine Histatherin to human Histatin is 21% and that it is 37% similar to human Statherin. There is also a 39% similarity to the bovine form of Statherin. However, the Histatherin gene is not found in all species. Analysis of the genome of mice, rats, humans, cows, dogs and opossums discovered that of these, the Histatherin gene is present only in the genome of dogs and cattle.
Significance in milk Histatherin is expressed in the lactation phase and is secreted into milk from the mammary gland.One of the antimicrobial compounds in bovine milk.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1 predicted disordered segment; (16-58)
DisProt Annotation
TM Helix Prediction 1 TMH; (4-22) transmembrane protein