Primary Information |
---|
BoMiProt ID | Bomi6228 |
---|
Protein Name | Hepatocyte nuclear factor 3-gamma/HNF-3-gamma/Forkhead box protein A3 |
---|
Organism | Bos taurus |
---|
Uniprot ID | Q3Y598 |
---|
Milk Fraction | Whey |
---|
Ref Sequence ID | NP_001028291.1 |
---|
Aminoacid Length | 351 |
---|
Molecular Weight | 37138 |
---|
FASTA Sequence |
Download |
---|
Gene Name | FOXA3/HNF3G |
---|
Gene ID | 503622 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Protein Function | Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes |
---|
Significance in milk | Glucose homeostasis.also involved in negative energy balance which is an altered metabolic state, occurs in early postpartum dairy cattle when energy demands to support lactation exceed energy intake. |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
---|
Predicted Disorder Regions | (27-33), (46-113), (215-230), (239-274), (300-306), (320-331) |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |
---|
Bibliography | 1.Fatima, A., Waters, S., O'Boyle, P., Seoighe, C., & Morris, D. G. (2014). Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. BMC genomics, 15, 28. https://doi.org/10.1186/1471-2164-15-28 2.Hiemisch, H., Schütz, G., & Kaestner, K. H. (1997). Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis. The EMBO journal, 16(13), 3995–4006. https://doi.org/10.1093/emboj/16.13.3995 |