Primary Information |
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| BoMiProt ID | Bomi6227 |
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| Protein Name | Hepatocyte growth factor/Hepatopoietin-A/Scatter factor/SF |
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| Organism | Bos taurus |
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| Uniprot ID | Q76BS1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001026921.1 |
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| Aminoacid Length | 730 |
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| Molecular Weight | 83357 |
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| FASTA Sequence |
Download |
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| Gene Name | HGF |
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| Gene ID | 282879 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Potent mitogen for mature parenchymal hepatocyte cells.known to promote growth of hepatocytes.imp for synaptic plasticity.involved in breakdown of the extracellular matrix.Suppression of chronic inflammation. |
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| Biochemical Properties | a heparin-binding protein.contains disulfide bond linked light and heavy chains.Binds to Met receptor.HGF contains NK1 domain which is important for high affinity binding to Met and Met dimerization and A Beta chain domain which has low affinity for Met Receptor. |
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| PTMs | disulfide bond formation,Glycosylation.Proteolytic cleavage |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (7-29) |
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| Significance of PTMs | HGF is biosynthesized as a prepro-form of 728 amino acids, including a signal sequence and both α- and β-chains. After cleavage of a signal peptide of the first 31 amino acids, a single-chain HGF is further cleaved between Arg494 and Val495, and this processing is coupled to the conversion of biologically inactive pro-HGF to active HGF. |
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| Linking IDs | |
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