|Protein Name||BOLA class I histocompatibility antigen, alpha chain BL3-6|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Protein Function||major histocompatibility complex (MHC) of cattle is known as the bovine leukocyte antigen (BoLA) and is located on chromosome 23; linked to variation in resistance to disease including bovine leukemia virus-induced lymphoma and mastitis|
|Biochemical Properties||existence of up three expressed class I loci in cattle|
|Significance in milk||influence traits such as milk yield, growth and reproduction, which are not often measured in humans, and variations in individual immune response to antigen; likely to play an important role in cattle immune responses|
|PTMs||Disulfide bond formation,N-Linked Glycosylation at Asn, Phosphorylation at Ser|
| Site(s) of PTM(s) |
|Predicted Disorder Regions||61-73,247-254,334-360|
|TM Helix Prediction||1TMH; (303-325)|
|Bibliography||1. Weigel, K. A., Freeman, A. E., Kehrli, M. E., Stear, M. J., & Kelley, D. H. (1990). Association of class I bovine lymphocyte antigen complex alleles with health and production traits in dairy cattle. Journal of Dairy Science, 73(9), 2538–2546. https://doi.org/10.3168/jds.S0022-0302(90)78939-4. |
2. Joosten, I., Teale, A. J., van der Poel, A., & Hensen, E. J. (1992). Biochemical evidence of the expression of two major histocompatibility complex class I genes on bovine peripheral blood mononuclear cells. Animal Genetics, 23(2), 113–123. https://doi.org/10.1111/j.1365-2052.1992.tb00030.
3. Joosten, I., Sanders, M. F., & Hensen, E. J. (1991). Involvement of major histocompatibility complex class I compatibility between dam and calf in the aetiology of bovine retained placenta. Animal Genetics, 22(6), 455–463. https://doi.org/10.1111/j.1365-2052.1991.tb00717.
4. al-Murrani, S. W., Glass, E. J., & Hopkins, J. (1994). BoLA class I charge heterogeneity reflects the expression of more than two loci. Animal Genetics, 25(3), 165–172. https://doi.org/10.1111/j.1365-2052.1994.tb00105.