Primary Information |
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| BoMiProt ID | Bomi6182 |
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| Protein Name | H2.0-like homeobox protein/Homeobox protein HLX1 |
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| Organism | Bos taurus |
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| Uniprot ID | A7MB54 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence ID | NP_001094567.1 |
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| Aminoacid Length | 486 |
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| Molecular Weight | 50415 |
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| FASTA Sequence |
Download |
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| Gene Name | HLX |
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| Gene ID | 519165 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.H2.0-like homeobox 1 (HLX1) is a homeobox transcription factor gene expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta and involved in the development of enteric nervous system. |
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| PTMs | Ubiquitination at Lys175,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 3 disordered segments; (86-155), (168-177), (357-483) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | increased levels of nonclustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and blocked differentiation.Inhibition of HLX Leads to Decreased Cell Cycling, Increased Cell Death, and Differentiation of AML Cells and Causes Significant Changes in Gene Expression |
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| Bibliography | Kawahara M, Pandolfi A, Bartholdy B, Barreyro L, Will B, Roth M, Okoye-Okafor UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell. 2012 Aug 14;22(2):194-208. doi: 10.1016/j.ccr.2012.06.027. PMID: 22897850; PMCID: PMC3422691. |
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