Primary Information |
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| BoMiProt ID | Bomi6180 |
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| Protein Name | H(+)/Cl(-) exchange transporter 7/Chloride channel 7 alpha subunit/Chloride channel protein 7/ClC-7 |
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| Organism | Bos taurus |
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| Uniprot ID | Q4PKH3 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001020502.1 |
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| Aminoacid Length | 809 |
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| Molecular Weight | 88831 |
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| FASTA Sequence |
Download |
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| Gene Name | CLCN7 |
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| Gene ID | 513545 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | voltage-gated channel mediating the exchange of chloride ions against proton.acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. |
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| Biochemical Properties | functions as antiporter.2 chloride(in) + H+(out) = 2 chloride(out) + H+(in). presence of conserved gating glutamate residues is imp for its function. |
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| PTMs | phosphorylation on ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 11TMHs; (130-152), (179-201), (231-249), (292-314), (327-349), (381-403), (416-438), (492-510), (517-539), (551-573), (580-602) |
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| Additional Comments | Loss of CLC-7 transporters leads to lysosomal storage diseases and osteopetrosis |
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| Bibliography | Lin J, Wei J, Lv Y, Zhang X, Yi RF, Dai C, Zhang Q, Jia J, Zhang D, Huang Y. H(+)/Cl(‑) exchange transporter 7 promotes lysosomal acidification‑mediated autophagy in mouse cardiomyocytes. Mol Med Rep. 2021 Mar;23(3):222. doi: 10.3892/mmr.2021.11861. Epub 2021 Jan 26. PMID: 33495814; PMCID: PMC7845584. |
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