Primary Information |
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| BoMiProt ID | Bomi6173 |
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| Protein Name | Guanine nucleotide-binding protein-like 3-like protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T0J9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029479.1 |
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| Aminoacid Length | 575 |
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| Molecular Weight | 64837 |
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| FASTA Sequence |
Download |
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| Gene Name | GNL3L |
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| Gene ID | 507679 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-κB pathway during tumorigenesis. |
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| Biochemical Properties | A Novel Lysine-rich Domain and GTP Binding Motifs Regulate the Nucleolar Retention of Human Guanine Nucleotide Binding Protein, GNL3L. |
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| PTMs | Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-31, 491-510, 571-575 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | mutations within the G-domains alter the GTP binding ability of GNL3L and abrogate wild-type nucleolar retention even in the presence of functional NoLS |
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| Bibliography | 1.Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. J Mol Biol. 2006 Dec 8;364(4):637-54. doi: 10.1016/j.jmb.2006.09.007. Epub 2006 Sep 8. PMID: 17034816. 2.Thoompumkal IJ, Rehna K, Anbarasu K, Mahalingam S. Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation. Cell Cycle. 2016 Dec;15(23):3251-3267. doi: 10.1080/15384101.2016.1242534. Epub 2016 Oct 20. PMID: 27764577; PMCID: PMC5176145. |
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