Primary Information |
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| BoMiProt ID | Bomi6140 |
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| Protein Name | Growth/differentiation factor 10(GDF 10)/Bone morphogenetic protein 3B(BMP 3B) |
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| Organism | Bos taurus |
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| Uniprot ID | Q08DX6 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence ID | NP_001069635.1 |
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| Aminoacid Length | 478 |
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| Molecular Weight | 52626 |
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| FASTA Sequence |
Download |
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| Gene Name | GDF10/BMP3B |
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| Gene ID | 539510 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | also known as BMP-3b,capable of inhibiting osteoblast differentiation by antagonizing BMP-2 and -4 -mediated osteogenesis.Acts as a regulator of hepatic PPARγ during conditions of dietary stress. |
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| Biochemical Properties | member of the TGFβ superfamily |
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| PTMs | Cleavage on pair of basic residues, Disulfide bond formation, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08DX6|GDF10_BOVIN Growth/differentiation factor 10 OS=Bos taurus OX=9913 GN=GDF10 PE=2 SV=1
MARGPARTSLGPGSQQLPLLSLLLLLLLRDADGSHTAAARPPPPAAADGLAGDKNPQRSP
GDVAAAQSPGAQDMVAVHMLRLYEKYSRRGARPGGGNTVRSFRARLEVVNQKAVYFFN*118LT
SMQDSEMILTATFHFYSEPQWPPAREVPCKQRAKN*155ASCRLLPPGPPARQHLLFRSLSQNT
ATQGLLRGAMALPPPPRGLWQAKDISLIVKAARRDGELLLSAQLDSGEKDTGVPRLGPHA
PYILIYANDLAISEPNSVAVTLQRYDPFQAGDPEPGAAPN*280SSADPRVRRATQATGPLQNN
ELPGLDERPAQAPHAQHYHKHELWPNPLRALKPRPGRKDRRKKGQDVFMASSQVLDFDEK
TMQKARKKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCSGACEFPMPKMVRPS
NHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPN*469MSVETCACR |
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| Predicted Disorder Regions | 4-14, 35-71, 146-163, 275-283, 336-345 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | In vitro knockdown of GDF10 enhances adipogenesis and that transgenic mice overexpressing GDF10 are protected against diet-induced obesity and insulin resistance. |
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| Bibliography | Platko K, Lebeau PF, Byun JH, Poon SV, Day EA, MacDonald ME, Holzapfel N, Mejia-Benitez A, Maclean KN, Krepinsky JC, Austin RC. GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury. Mol Metab. 2019 Sep;27:62-74. doi: 10.1016/j.molmet.2019.06.021. Epub 2019 Jun 28. PMID: 31288993; PMCID: PMC6717799. |
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