Primary Information |
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| BoMiProt ID | Bomi6118 |
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| Protein Name | GRB2-associated-binding protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLU3 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001094671.1 |
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| Aminoacid Length | 694 |
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| Molecular Weight | 76435 |
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| FASTA Sequence |
Download |
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| Gene Name | GAB1 |
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| Gene ID | 540085 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. |
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| PTMs | Acetylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLU3|GAB1_BOVIN GRB2-associated-binding protein 1 OS=Bos taurus OX=9913 GN=GAB1 PE=2 SV=1
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
EEDPVKAPGSSLQAPADIPLAISTAPPSSQVGASAAAAPPPYQLISLPPHLETLGIQEDP
QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGVNGFFQQHM
MYDSPPSRAAS*251LS*253VDSSLYNLPRSYS*266HDVLPKVSPSSTEADGELYVFNTPSGTSSVEPQM
RHVS*304ISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVDTC
SITRTASDTDSSYCIPTAGLPPSRSNT*387ISTVDLNKLRKDASS*402QDCYDTPRTFPSDRSSSL
EGFHNHFKIKNILTAGSVSSEELDENYVPMNPNS*454PPRQHSSSFTEPIQEANYVPMTPGTF
DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLP
EWEELQAPVRSPITRSFARDSSRFPLSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSED
SNLFGSNSLDGGNSPMIKPKGDKQVEY*627LDLDLDSGKST*638PPRKQKSSGSGSS*651VADERVDY*659VVVDQQKTLALKSTREAWTDGRQS*683TESETPAKNVK |
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| Predicted Disorder Regions | 146-166, 201-230, 253-276, 331-340, 366-384 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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