Search by BoMiProt ID - Bomi6064

Primary Information

BoMiProt ID Bomi6064
Protein Name Glycolipid transfer protein
Organism Bos taurus
Uniprot IDP68265
Milk FractionWhey
Ref Sequence ID NP_786993.1
Aminoacid Length 209
Molecular Weight 23922
FASTA Sequence Download
Gene Name GLTP
Gene ID 327678
Protein Existence Status reviewed

Secondary Information

Protein Function Glycolipid transfer protein (GL-TP) participates in the intracellular traffic of glucosylceramide.
Biochemical Properties The glycolipid transfer protein (GLTP) is a protein capable of binding and transferring glycolipids. GLTP is cytosolic and it can interact through its FFAT-like (two phenylalanines in an acidic tract) motif with proteins localized on the surface of the endoplasmic reticulum.
PTMs Acetylation at Lys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Glycolipid transfer protein, GLTP
Superfamily : Glycolipid transfer protein, GLTP
Family : Glycolipid transfer protein, GLTP
Domain Name : 1TFJ A:6-209

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Glycolipid transfer protein (GLTP) catalyzes selective intermembrane transfer of GSLs. To enable effective use of GLTP as a tool to modify the glycolipid content of membranes
Bibliography 1.Sasaki T. Glycolipid transfer protein and intracellular traffic of glucosylceramide. Experientia. 1990 Jun 15;46(6):611-6. doi: 10.1007/BF01939700. PMID: 2193825. 2.Rao CS, Chung T, Pike HM, Brown RE. Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. Biophys J. 2005 Dec;89(6):4017-28. doi: 10.1529/biophysj.105.070631. Epub 2005 Sep 16. PMID: 16169991; PMCID: PMC1366967. 3.Ohvo-Rekilä H, Mattjus P. Monitoring glycolipid transfer protein activity and membrane interaction with the surface plasmon resonance technique. Biochim Biophys Acta. 2011 Jan;1808(1):47-54. doi: 10.1016/j.bbamem.2010.08.018. Epub 2010 Sep 8. PMID: 20804726.