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Primary Information | |
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| BoMiProt ID | Bomi6064 |
| Protein Name | Glycolipid transfer protein |
| Organism | Bos taurus |
| Uniprot ID | P68265 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_786993.1 |
| Aminoacid Length | 209 |
| Molecular Weight | 23922 |
| FASTA Sequence | Download |
| Gene Name | GLTP |
| Gene ID | 327678 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Glycolipid transfer protein (GL-TP) participates in the intracellular traffic of glucosylceramide. |
| Biochemical Properties | The glycolipid transfer protein (GLTP) is a protein capable of binding and transferring glycolipids. GLTP is cytosolic and it can interact through its FFAT-like (two phenylalanines in an acidic tract) motif with proteins localized on the surface of the endoplasmic reticulum. |
| PTMs | Acetylation at Lys |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : All alpha proteins Fold : Glycolipid transfer protein, GLTP Superfamily : Glycolipid transfer protein, GLTP Family : Glycolipid transfer protein, GLTP Domain Name : 1TFJ A:6-209 |
| CATH | Matched CATH superfamily 1.10.3520.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1TFJ, 1WBE, 2BV7, |
| Additional Comments | Glycolipid transfer protein (GLTP) catalyzes selective intermembrane transfer of GSLs. To enable effective use of GLTP as a tool to modify the glycolipid content of membranes |
| Bibliography | 1.Sasaki T. Glycolipid transfer protein and intracellular traffic of glucosylceramide. Experientia. 1990 Jun 15;46(6):611-6. doi: 10.1007/BF01939700. PMID: 2193825. 2.Rao CS, Chung T, Pike HM, Brown RE. Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. Biophys J. 2005 Dec;89(6):4017-28. doi: 10.1529/biophysj.105.070631. Epub 2005 Sep 16. PMID: 16169991; PMCID: PMC1366967. 3.Ohvo-Rekilä H, Mattjus P. Monitoring glycolipid transfer protein activity and membrane interaction with the surface plasmon resonance technique. Biochim Biophys Acta. 2011 Jan;1808(1):47-54. doi: 10.1016/j.bbamem.2010.08.018. Epub 2010 Sep 8. PMID: 20804726. |