Primary Information |
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| BoMiProt ID | Bomi6043 |
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| Protein Name | Glutathione hydrolase 6/Gamma-glutamyltransferase 6/Gamma-glutamyltranspeptidase 6 |
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| Organism | Bos taurus |
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| Uniprot ID | A7YWM1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001098904.1 |
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| Aminoacid Length | 490 |
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| Molecular Weight | 49626 |
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| FASTA Sequence |
Download |
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| Gene Name | GGT6 |
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| Gene ID | 613919 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | role in glutathione homeostatsis.it hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. As such, it has a critical function in the metabolism of glutathione and in the conversion of the leukotriene LTC4 to LTD4. |
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| Biochemical Properties | GGT hydrolyzes γ-glutamyl peptides but can also catalyze the transfer of γ-glutamyl groups between different compounds. |
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| PTMs | N-linked glycosylation on asparagine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7YWM1|GGT6_BOVIN Glutathione hydrolase 6 OS=Bos taurus OX=9913 GN=GGT6 PE=2 SV=1
MEPEAGPVLYQKLRVWEPSLESEEEEEEISEQLILDASGPHDSSGNKAGRLPGAWAQLVA
ALLLLAIGFSLAVRQLCSSGASPGALGSGAPPASGHSHRPGVYHHGAIISPAAECSRLGR
ELFVAGGNIVDAGVGAALCLAVVHPHTTGLGATYWGLFHN*160SSSGN*165STALTSGPAQTLAPG
LGLPSALPALHMLHTHFGRLPWPHLLVGPISLAQKGFLVDTSLASALAAQDTKGLCPLLC
HANGTPLGPGTQVTNTKLAAVLHKASLAPTPDLSGDALLSLLAEDLGLEGPSVGPRPTLE
PALQLPLPQGILFTTPSPSAGPELLELLEASLQSAGPSPAPCPALPQAAAAPRSSVLATV
DSSGSVLLLTSSLN*374SSFGSGHLSPSTGVLLSNLVAESAAGAWACPLIFRDISDDTEVDVL
GLVASGTPAAARVMTHALLSHLARPQTPDQQGPTESPRACAQGTLLQVAAHTEHAHVSSV
PSGCCPFQGF |
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| Predicted Disorder Regions | 5 disordered segments; (18-25), (41-46), (86-99), (335-348), (445-462) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Heisterkamp N, Groffen J, Warburton D, Sneddon TP. The human gamma-glutamyltransferase gene family. Hum Genet. 2008 May;123(4):321-32. doi: 10.1007/s00439-008-0487-7. Epub 2008 Mar 21. PMID: 18357469. |
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