Primary Information |
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| BoMiProt ID | Bomi5973 |
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| Protein Name | General transcription factor IIE subunit 1/Transcription initiation factor IIE subunit alpha/TFIIE-alpha |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLI8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001096764.1 |
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| Aminoacid Length | 438 |
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| Molecular Weight | 49211 |
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| FASTA Sequence |
Download |
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| Gene Name | GTF2E1 |
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| Gene ID | 540525 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | TFIIE helps in the recruitment of TFII regulates TFIIH kinase activity that phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. |
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| Biochemical Properties | TFIIE binds Gal11 protein, a component of the Mediator, and that TFIIE-Gal11 interaction en-hances TFIIH-catalyzed phosphorylation of the CTD. |
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| PTMs | Acetylation Ala and Lys and phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLI8|T2EA_BOVIN General transcription factor IIE subunit 1 OS=Bos taurus OX=9913 GN=GTF2E1 PE=2 SV=1
MADPDVLTEVPAALKRLAKYVIRGFYGIEHALALDILIRNPCVKEEDMLELLKFDRKQLR
SVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERD
STNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCQTEVEEDESAMPKKDARTLLARF
NEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDRAATAAGAAGLAGGHHREAWT
TKGPSYEDLYTQNVVINMDDQEDLHRAS*268LEGKSAKERPIWLRESTVQGAYNSEEMKEGGI
DIDSFQEHEEGHAGPDDNEEVMRALLIHEKKTPSAPAGSVGAAAPVTAANGSDSESETSE
SDDDSPPRVATVAAHHGEEDEEDDEFEEVADDPVVMVAGRPFSYSEVSQKPELVAQMTPE
EKEAYIAMGQRMFEDLFE |
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| Predicted Disorder Regions | 215-251, 261-410, 419-423, |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Sakurai H, Fukasawa T. Activator-specific requirement for the general transcription factor IIE in yeast. Biochem Biophys Res Commun. 1999 Aug 11;261(3):734-9. doi: 10.1006/bbrc.1999.1113. PMID: 10441494. |
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