Primary Information |
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| BoMiProt ID | Bomi5971 |
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| Protein Name | General transcription and DNA repair factor IIH helicase subunit XPB/TFIIH subunit XPB/DNA excision repair protein ERCC-3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q1RMT1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039453.1 |
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| Aminoacid Length | 782 |
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| Molecular Weight | 89193 |
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| FASTA Sequence |
Download |
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| Gene Name | ERCC3 |
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| Gene ID | 507984 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA.ATP-dependent 3'-5' DNA helicase,component of the general transcription and DNA repair factor IIH (TFIIH) core complex. |
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| PTMs | Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q1RMT1|ERCC3_BOVIN General transcription and DNA repair factor IIH helicase subunit XPB OS=Bos taurus OX=9913 GN=ERCC3 PE=2 SV=1
MGKRDRADREKKKSKKRHYEDEEDEEDDAPGNDTQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITDYLRKLSKTGVPEGIIQFIKLCTVSYGKVKLVLKHNRYFVESS
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAIAKSVEGSGGPSTSRVTDPQG
KSDIPTDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSIAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNSGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYS*686FKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSKSSQVSRRFGTMSSMSGADDTVYMEYHSSRSKTSTKHVHPLFKRF
RK |
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| Predicted Disorder Regions | 1-58, 205-268, 768-777 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
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| Bibliography | Hubank M, Mayne L. Expression of the excision repair gene, ERCC3 (excision repair cross-complementing), during mouse development. Brain Res Dev Brain Res. 1994 Aug 12;81(1):66-76. doi: 10.1016/0165-3806(94)90069-8. PMID: 7805288. |
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