Primary Information |
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| BoMiProt ID | Bomi5939 |
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| Protein Name | Gap junction delta-2 protein/Connexin-36/Gap junction alpha-9 protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q866T7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777108.1 |
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| Aminoacid Length | 321 |
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| Molecular Weight | 36126 |
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| FASTA Sequence |
Download |
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| Gene Name | GJD2/GJA9 |
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| Gene ID | 282577 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
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| Biochemical Properties | gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 114-186, 284-292, 306-321 |
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| DisProt Annotation | |
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| TM Helix Prediction | 4TMHs; (20-42), (76-98), (198 220), (252 270) |
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| Significance of PTMs | Two important modulators are dopamine and adenosine which control phosphorylation and dephosphorylation. Cx35/Cx36 remains in a dephosphorylated (uncoupled) state under bright lighting conditions. High-illuminant light inhibits ocular growth through the uncoupling of retinal gap junctions.Light-directed Cx35/36 (de)phosphorylation has been described to be regulated by dopamine signaling (effect: dephosphorylation/uncoupling) and and adenosine signaling (effect: phosphorylation/coupling). |
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| Bibliography | 1.Quint, W.H., Tadema, K.C.D., de Vrieze, E. et al. Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Commun Biol 4, 676 (2021). https://doi.org/10.1038/s42003-021-02185-z |
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