Primary Information |
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| BoMiProt ID | Bomi5938 |
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| Protein Name | Gap junction beta-2 protein/Connexin-26 |
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| Organism | Bos taurus |
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| Uniprot ID | A2VE67 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001077106.1 |
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| Aminoacid Length | 226 |
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| Molecular Weight | 26194 |
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| FASTA Sequence |
Download |
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| Gene Name | GJB2 |
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| Gene ID | 407154 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | is essential for maintaining the high K+ concentration in the endolymph of the inner ear.consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
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| PTMs | Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | (219-226) |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | Hearing impirment due to mutation of this gene. |
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| Bibliography | Kemperman, M. H., Hoefsloot, L. H., & Cremers, C. W. (2002). Hearing loss and connexin 26. Journal of the Royal Society of Medicine, 95(4), 171–177. https://doi.org/10.1258/jrsm.95.4.171 |
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