Primary Information |
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| BoMiProt ID | Bomi5930 |
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| Protein Name | Gamma-aminobutyric acid receptor subunit alpha-3/GABA(A) receptor subunit alpha-3 |
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| Organism | Bos taurus |
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| Uniprot ID | P10064 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776967.1 |
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| Aminoacid Length | 492 |
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| Molecular Weight | 55284 |
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| FASTA Sequence |
Download |
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| Gene Name | GABRA3 |
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| Gene ID | 282237 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Gamma-aminobutyric acid (GABA) receptors |
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| Biochemical Properties | heteromeric pentameric ligand-gated ion channels |
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| PTMs | Phosphorylation.Glycosylation,Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P10064|GBRA3_BOVIN Gamma-aminobutyric acid receptor subunit alpha-3 OS=Bos taurus OX=9913 GN=GABRA3 PE=2 SV=1
MIITQMSQFYMAGLGLLFLINILPGTTGQVESRRQEPGDFVKQDIGGLSPKHAPDIPDDS
TDN*63ITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ
TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHN*163MTTPNKLLRLVDN*176GTLL
YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKN*228KSVEVAQDGSRL
NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN
RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALIEFATVN
YFTKRSWAWEGKKVPEALEMKKKTPAVPTKKTSTTFNIVGTTYPINLAKDTEFSAISKGA
APSTSS*226T*227PTIIAS*233PKTTCVQDIPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN
RESAIKGMIRKQ |
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| Predicted Disorder Regions | 29-61 |
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| DisProt Annotation | |
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| TM Helix Prediction | 5TMHs; (7-25, (275-297), (304-325), (340-362), (461-479) |
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| Significance of PTMs | phosphorylation sites located on the cytoplasmic domain between TM3 and TM4 of the α, β, and γ subunits |
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| Additional Comments | Gabra3 promotes breast cancer invasion and metastasis |
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| Bibliography | Gumireddy K, Li A, Kossenkov AV, Sakurai M, Yan J, Li Y, Xu H, Wang J, Zhang PJ, Zhang L, Showe LC, Nishikura K, Huang Q. The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis. Nat Commun. 2016 Feb 12;7:10715. doi: 10.1038/ncomms10715. PMID: 26869349; PMCID: PMC4754346. |
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