Search by BoMiProt ID - Bomi5925

Primary Information

BoMiProt ID Bomi5925
Protein Name Galectin-1/14 kDa lectin Beta-galactoside-binding lectin L-14-I/Galaptin/Lactose-binding lectin 1/Lectin galactoside-binding soluble 1/S-Lac lectin 1
Organism Bos taurus
Uniprot IDP11116
Milk FractionWhey
Ref Sequence ID NP_786976.1
Aminoacid Length 135
Molecular Weight 14744
FASTA Sequence Download
Gene Name LGALS1
Gene ID 326598
Protein Existence Status reviewed

Secondary Information

Protein Function Galectin-1 is located in the caruncular and intercaruncular regions of the bovine endometrium.These are Beta-galactoside-binding proteins modulating cell-cell and cell-matrix interactions. autocrine negative growth factor .Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. creating immune tolerance in pregnancy.
Biochemical Properties Contains a carbohydrate recognition domain (CRD) responsible for binding to B-galactosides.Commonly they are homodimers of two identical galectin subunits although they can also function as monomers.The N-terminal domain allows for multimerization and crosslinking between galectin proteins, each containing a CRD.
Significance in milk Galectin-1 was found to be a differentially expressed gene in the endometrium of AI pregnant cows when compared to cyclic cows. It has been implicated in the process of decidualization, the transformation of endometrial stroma into a specialized tissue that supports trophoblast invasion and provides nourishment to the conceptus before the establishment of a definite placenta
PTMs Acetylation, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All beta proteins
Fold : Concanavalin-like
Superfamily : Concanavalin A-like lectins/glucanases
Family : Galectin (animal S-lectin)
Domain Name : 1SLT A:2-134

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape.Galectin-1 preferentially bound to neutrophils, plasma cells and enterocytes.
Bibliography 1. 2.Abbott WM, Feizi T. Soluble 14-kDa beta-galactoside-specific bovine lectin. Evidence from mutagenesis and proteolysis that almost the complete polypeptide chain is necessary for integrity of the carbohydrate recognition domain. J Biol Chem. 1991 Mar 25;266(9):5552-7. PMID: 1900835.