|
|
|
Primary Information | |
|---|---|
| BoMiProt ID | Bomi5925 |
| Protein Name | Galectin-1/14 kDa lectin Beta-galactoside-binding lectin L-14-I/Galaptin/Lactose-binding lectin 1/Lectin galactoside-binding soluble 1/S-Lac lectin 1 |
| Organism | Bos taurus |
| Uniprot ID | P11116 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_786976.1 |
| Aminoacid Length | 135 |
| Molecular Weight | 14744 |
| FASTA Sequence | Download |
| Gene Name | LGALS1 |
| Gene ID | 326598 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Galectin-1 is located in the caruncular and intercaruncular regions of the bovine endometrium.These are Beta-galactoside-binding proteins modulating cell-cell and cell-matrix interactions. autocrine negative growth factor .Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. creating immune tolerance in pregnancy. |
| Biochemical Properties | Contains a carbohydrate recognition domain (CRD) responsible for binding to B-galactosides.Commonly they are homodimers of two identical galectin subunits although they can also function as monomers.The N-terminal domain allows for multimerization and crosslinking between galectin proteins, each containing a CRD. |
| Significance in milk | Galectin-1 was found to be a differentially expressed gene in the endometrium of AI pregnant cows when compared to cyclic cows. It has been implicated in the process of decidualization, the transformation of endometrial stroma into a specialized tissue that supports trophoblast invasion and provides nourishment to the conceptus before the establishment of a definite placenta |
| PTMs | Acetylation, Phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : All beta proteins Fold : Concanavalin-like Superfamily : Concanavalin A-like lectins/glucanases Family : Galectin (animal S-lectin) Domain Name : 1SLT A:2-134 |
| CATH | Matched CATH superfamily 2.60.120.20 2.60.120.200 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1SLA,1SLB,1SLC,1SLT., |
| Additional Comments | Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape.Galectin-1 preferentially bound to neutrophils, plasma cells and enterocytes. |
| Bibliography | 1.https://doi.org/10.33915/etd.4088 2.Abbott WM, Feizi T. Soluble 14-kDa beta-galactoside-specific bovine lectin. Evidence from mutagenesis and proteolysis that almost the complete polypeptide chain is necessary for integrity of the carbohydrate recognition domain. J Biol Chem. 1991 Mar 25;266(9):5552-7. PMID: 1900835. |