Primary Information |
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| BoMiProt ID | Bomi5900 |
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| Protein Name | G protein-coupled receptor 161 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2YDN1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070534.1 |
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| Aminoacid Length | 528 |
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| Molecular Weight | 58349 |
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| FASTA Sequence |
Download |
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| Gene Name | GPR161 |
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| Gene ID | 768006 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | acts as a Gαs-coupled receptor and activates PKA, a central negative regulator of Hh signaling |
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| Biochemical Properties | AKAP motif embedded in its C-terminal tail |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2YDN1|GP161_BOVIN G protein-coupled receptor 161 OS=Bos taurus OX=9913 GN=GPR161 PE=2 SV=1
MSLN*4SSLGHRKELSN*15LTEGASDQGGSGVTEFVAIVIITVFVCLGNLVIVITLYRKSYLLT
LSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCN*101FSALLYLLISSASMLTLGI
IAVDRYYAVLYPMAYPMKITGNRAVMVLAYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVA
AWHREPGYTAFWQIWCALLPFLVMLVCYGFIFRVARVKARKVHCGAVVTVEVGVQRTGRK
NSSTSTSSSGSRKSAFQGVVYSANQCKALVTILVVIGAFMVTWGPYMVVITSEALWGKNC
VSPTLETWATWLSFTSAICHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFS
ISNRITDLGLSPHLTALMAGEQPLGNSSSTGDTGFSCSQDSGTDVMLLEDYTSDDNPLHG
TCPPKRRSSVTFEDEVEQIKEAAKNPILHVKADVHKSLDSYATSLAKAIEAEAKINLFGE
EALPGVLLTARTVPGIGFGSRRGSRTLAGQRLQLQSIEEGDVLATEQR |
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| Predicted Disorder Regions | 1-20, 240-249, 379-442, 520-527 |
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| DisProt Annotation | |
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| TM Helix Prediction | 7TMHs; (31-53),(66-84),(93-123),(144-166),(190-212),(268-290),(309-327) |
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| Significance of PTMs | Gpr161 is phosphorylated by PKA at the PKA consensus site position RRSS429 which is imp for GPCR-cAMP signaling. |
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| Bibliography | 1.Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91. doi: 10.1073/pnas.1608061113. Epub 2016 Jun 28. PMID: 27357676; PMCID: PMC4948347. |
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