Primary Information |
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| BoMiProt ID | Bomi5881 |
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| Protein Name | G patch domain-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q24K12 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069246.1 |
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| Aminoacid Length | 931 |
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| Molecular Weight | 103602 |
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| FASTA Sequence |
Download |
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| Gene Name | GPATCH1/GPATC1 |
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| Gene ID | 518738 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | SUGP1 acts as a novel regulator of cholesterol metabolism and suggest that it contributes to the relationship between rs10401969 and plasma cholesterol. |
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| Biochemical Properties | The SUGP1 protein is predicted to contain two SURP motifs, domains of alternative splicing regulators thought to be involved in RNA binding as well as a G-patch domain, a region of six highly conserved glycine residues commonly found in eukaryotic RNA-processing proteins |
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| PTMs | Acetylation at Ala, Isopeptide bond formation, Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q24K12|GPTC1_BOVIN G patch domain-containing protein 1 OS=Bos taurus OX=9913 GN=GPATCH1 PE=2 SV=1
MAALDS*6DS*8DEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAG
YFNTVGSKEGWTPSSFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKSIVTTDDFASKT
KDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGIGPRVKRRPR
RQKPDPGVKIYGCALPPGGSEGSEDEDDDYLPENVTFAPKDVTPVDFTPKDNVHGLAYKG
LDPHQALFGTSGEHFNLFSGGPEETGDLLGDIGVNKGRKLGISGQAFGVGALEEEDDDIY
ATETLSKYDTVLKDEEPGDGLYGWTAPRQYKSQKESEKDLCYVGKILDGFSLASKPLS*358SK
KIYPPPELPRDYRPVHYFRPVVAATSENSHLLQVLSESAGKPTNDPGTRSRHQLNACKRG
ELLGETPIQGAPTSVLEFLSQKDKERLKEVKQATDLKAAQLRARSLAQSASGSRPQPLS*479P
DVGHCSWHMALSGGMASTRTSNFKPFAKDPEKQKRYEEFLANMKRGQKDALERCLDPGMT
EWERGRERDEFARAALLYASSHSTLSSRFTHAQEEDDSEQVEVPRDQENDVSDKQSAVKM
KMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVKRDKYSVFNFLTIPETASSP
VTQASSEKVAQHRASDKSRKPSRWDTSKEEKKEDSISEFLSLARSKVGPAKPEPS*715PLVNK
EEARATESVSNKVVNKDVDSQTEGEGSRPSMDLFKAIFASSSDEKSSSSEDEQGDSEDDQ
EGTREADFKSSQETDLVEASSVAQASEPAPQEPAPFFPIQKMQIDEREAFGPRLPPVFCP
NARQKLEAPLKEKHKKNKEKHKTKKEHRRKKEKKKKHRKHKHKGKQKNKKSEKSSSSEST
DSSDSQSEEGPTDLSPQELLRRLKRLPLRRQ |
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| Predicted Disorder Regions | 142-173, 558-580, 634-715, 746-822, 856-931 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | G patch domain containing 1 (SUGP1) is associated with coronary artery disease (CAD), plasma LDL cholesterol levels, and other energy metabolism phenotypes. |
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| Bibliography | 1.Kim MJ, Yu CY, Theusch E, Naidoo D, Stevens K, Kuang YL, Schuetz E, Chaudhry AS, Medina MW. SUGP1 is a novel regulator of cholesterol metabolism. Hum Mol Genet. 2016 Jul 15;25(14):3106-3116. doi: 10.1093/hmg/ddw151. Epub 2016 May 20. PMID: 27206982; PMCID: PMC5181593. 2.SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins. 3.G-patch: a new conserved domain in eukaryotic RNA-processing proteins and type D retroviral polyproteins.
Aravind L, Koonin EV
Trends Biochem Sci. 1999 Sep; 24(9):342-4.
Spikes DA, Kramer J, Bingham PM, Van Doren K
Nucleic Acids Res. 1994 Oct 25; 22(21):4510-9. 3. |
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