Primary Information
BoMiProt ID	Bomi5837
Protein Name	Forkhead box protein P1
Organism	Bos taurus
Uniprot ID	A4IFD2
Milk Fraction	whey
Ref Sequence ID	NP_001077158.1
Aminoacid Length	674
Molecular Weight	75121
FASTA Sequence	Download
Gene Name	FOXP1
Gene ID	515903
Protein Existence Status	reviewed
Secondary Information
Protein Function	It acts as a transcriptional repressor. It can function along with CTBP1 to repress transcription. It also plays an important role in the specification and differentiation of lung epithelial cells.
Biochemical Properties	Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding.It is a winged-helix DNA-binding transcription factor, belongs to subfamily P of the forkhead box transcription factor family.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|A4IFD2|FOXP1_BOVIN Forkhead box protein P1 OS=Bos taurus OX=9913 GN=FOXP1 PE=2 SV=1 MMQESGTETKSNGSAIQNGSSGGNHLLECGSLREGRSNGETPAVDVGTADLAHVQQQQQA LQVARQLLLQQQQQQQVSGLKS*82PKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVL SPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQHAGKQPKEQQQVATQQLAFQ QQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLTQGMIPTELQQLWKEVTSAHTTE ETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPL YGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERL QAMMTHLHVKSTEPKTAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPITPATQGPS VITTTSMHTVGPIRRRYSDKYNVPISSDIAQNQEFYKNAEVRPPFTYASLIRQAILESPE KQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQK RRPQKISGNPSLIKNMQTSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIR EELNGAMEHTNSNESDSSPGRSPLQAVHPVHVKEEPLDPEEAEGPLSLVT*650TANHS*655PDFDH DRDYEDEPVNEDME
Predicted Disorder Regions	8-28, 611-618, 648-674
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Liu, X. M., Du, S. L., Miao, R., Wang, L. F., & Zhong, J. C. (2022). Targeting the forkhead box protein P1 pathway as a novel therapeutic approach for cardiovascular diseases. Heart failure reviews, 27(1), 345–355. https://doi.org/10.1007/s10741-020-09992-2