Primary Information |
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| BoMiProt ID | Bomi5800 |
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| Protein Name | Ficolin-2/Collagen/fibrinogen domain-containing protein 2/Ficolin-B/Ficolin-beta/L-ficolin |
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| Organism | Bos taurus |
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| Uniprot ID | Q5I2E5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001010996.1 |
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| Aminoacid Length | 329 |
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| Molecular Weight | 35339 |
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| FASTA Sequence |
Download |
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| Gene Name | FCN2 |
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| Gene ID | 497016 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | soluble pattern recognition molecules that contribute to complement activation via the lectin pathway.ficolin-2 can bind to glycoproteins of pathogens including viral (Hepatitis C Virus, Influenza A virus and Human Immunodeficiency Virus) and virulent Mycobacterium tuberculosis and inhibit viral and bacterial infections.Ficolin-2 could bind to mannose-capped lipoarabinomannan . |
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| Significance in milk | Pathogen recognition molecules |
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| PTMs | Glycosylation,Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q5I2E5|FCN2_BOVIN Ficolin-2 OS=Bos taurus OX=9913 GN=FCN2 PE=2 SV=1
MELGGAAGALGPSGPLLVCLCFGTLAAQAADTCPEVKLVGLEGSDKLSILRGCPGLPGAP
GLKGETGAAGLKGERGLPGVPGKAGPAGPKGSTGAQGEKGARGEKGESGQLHSCATGPRT
CTELLTRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRKDGSVDFFRTWTAYKQ
GFGSQLGEFWLGNDNIHALTAQGTSELRVDLMDFEGNHRFAKYQSFRMADEAEKYKLVLG
AFVEGNAGDSLTDHGNHFFSTKDRDNDESPSNCAAQFQGAWWYHSCHSSNLNGRYLRGPH
TSYANGINWKSWGRYN*316YSYKVSEMKLRLT |
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| Predicted Disorder Regions | (66-98) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Ding Q, Shen Y, Li D, et al. Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells. Clinical Immunology (Orlando, Fla.). 2017 Oct;183:145-157. DOI: 10.1016/j.clim.2017.08.012. PMID: 28844702. |
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