Search by BoMiProt ID - Bomi5774


Primary Information

BoMiProt ID Bomi5774
Protein Name Fibrinogen alpha chain
Organism Bos taurus
Uniprot IDP02672
Milk FractionWhey,MFGM
Ref Sequence ID NP_001028798.1
Aminoacid Length 615
Molecular Weight 67012
FASTA Sequence Download
Gene Name FGA
Gene ID 522039
Protein Existence Status reviewed

Secondary Information

Protein Function Blood coagulation,adative immune system,positive regulation of ERK1 and ERK2 cascade,platelet aggregation.negatively regulates extrinsic apoptotic pathway via death domain receptors.
Biochemical Properties A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
Significance in milk acute phase response (acute inflammatory response, response to wounding, defense response, inflammatory response, acute-phase response).
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P02672|FIBA_BOVIN Fibrinogen alpha chain OS=Bos taurus OX=9913 GN=FGA PE=1 SV=5 MFSVRDLCLVLSLVGAIKTEDGSDPPSGDFLTEGGGVRGPRLVERQQSACKETGWPFCSD EDWNTKCPSGCRMKGLIDEVDQDFTSRINKLRDSLFNYQKNSKDSNTLTKNIVELMRGDF AKANNNDNTFKQISEDLRSRIEILRRKVIEQVQRIKVLQKNVRDQLVDMKRLEVDIDIKI RSCKGSCSRALEHKVDLEDYKNQQKQLEQVIAINLLPSRDIQYLPLIKMSTITGPVPREF KSQLQEAPLEWKALLEMQQTKMVLETFGGDGHARGDSVSQGTGLAPGSPRKPGTSSIGNV NPGSYGPGSSGTWNPGRPEPGSAGT*325WNPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEPG SAGTWNPGRPEPGSAGTWNTGSSGSSSFRPDSSGHGNIRPSSPDWGTFREEGSVSSGTKQ EFHTGKLVTTKGDKELLIDNEKVTSGHTTTTRRSCSKVITKTVTNADGRTETTKEVVKSE DGSDCGDADFDWHHTFPSRGNLDDFFHRDKDDFFTRSSHEFDGRTGLAPEFAALGESGSS SSKTSTHSKQFVSSSTTVNRGGSAIESKHFKMEDEAESLEDLGFKGAHGTQKGHTKARPA RGIHTSPLGEPSLTP
SCOP Class : All alpha proteins
Fold : Left-handed parallel coiled-coil
Superfamily : Fibrinogen coiled-coil and central regions
Family : Fibrinogen coiled-coil and central regions
Domain Name : 1JY2 N:35-77

CATH Matched CATH superfamily
1.20.5.50
Predicted Disorder Regions 6 predicted disorder segments; (24-49),(185-187),(269-417),(443-463),(481-598),(610-615)
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1DEQ,1JY2,1JY3,2BAF,2JOR,
Bibliography 1.Boggs I, Hine B, Smolenksi G, Hettinga K, Zhang L, Wheeler TT. Proteomics data in support of the quantification of the changes of bovine milk proteins during mammary gland involution. Data Brief. 2016 May 13;8:52-5. doi: 10.1016/j.dib.2016.05.013. PMID: 27274532; PMCID: PMC4885146. 2.Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005 Aug;3(8):1894-904. doi: 10.1111/j.1538-7836.2005.01365.x. PMID: 16102057.