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Primary Information | |
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| BoMiProt ID | Bomi5774 |
| Protein Name | Fibrinogen alpha chain |
| Organism | Bos taurus |
| Uniprot ID | P02672 |
| Milk Fraction | Whey,MFGM |
| Ref Sequence ID | NP_001028798.1 |
| Aminoacid Length | 615 |
| Molecular Weight | 67012 |
| FASTA Sequence | Download |
| Gene Name | FGA |
| Gene ID | 522039 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Blood coagulation,adative immune system,positive regulation of ERK1 and ERK2 cascade,platelet aggregation.negatively regulates extrinsic apoptotic pathway via death domain receptors. |
| Biochemical Properties | A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain. |
| Significance in milk | acute phase response (acute inflammatory response, response to wounding, defense response, inflammatory response, acute-phase response). |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P02672|FIBA_BOVIN Fibrinogen alpha chain OS=Bos taurus OX=9913 GN=FGA PE=1 SV=5 MFSVRDLCLVLSLVGAIKTEDGSDPPSGDFLTEGGGVRGPRLVERQQSACKETGWPFCSD EDWNTKCPSGCRMKGLIDEVDQDFTSRINKLRDSLFNYQKNSKDSNTLTKNIVELMRGDF AKANNNDNTFKQISEDLRSRIEILRRKVIEQVQRIKVLQKNVRDQLVDMKRLEVDIDIKI RSCKGSCSRALEHKVDLEDYKNQQKQLEQVIAINLLPSRDIQYLPLIKMSTITGPVPREF KSQLQEAPLEWKALLEMQQTKMVLETFGGDGHARGDSVSQGTGLAPGSPRKPGTSSIGNV NPGSYGPGSSGTWNPGRPEPGSAGT*325WNPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEPG SAGTWNPGRPEPGSAGTWNTGSSGSSSFRPDSSGHGNIRPSSPDWGTFREEGSVSSGTKQ EFHTGKLVTTKGDKELLIDNEKVTSGHTTTTRRSCSKVITKTVTNADGRTETTKEVVKSE DGSDCGDADFDWHHTFPSRGNLDDFFHRDKDDFFTRSSHEFDGRTGLAPEFAALGESGSS SSKTSTHSKQFVSSSTTVNRGGSAIESKHFKMEDEAESLEDLGFKGAHGTQKGHTKARPA RGIHTSPLGEPSLTP |
| SCOP | Class : All alpha proteins Fold : Left-handed parallel coiled-coil Superfamily : Fibrinogen coiled-coil and central regions Family : Fibrinogen coiled-coil and central regions Domain Name : 1JY2 N:35-77 |
| CATH | Matched CATH superfamily 1.20.5.50 |
| Predicted Disorder Regions | 6 predicted disorder segments; (24-49),(185-187),(269-417),(443-463),(481-598),(610-615) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1DEQ,1JY2,1JY3,2BAF,2JOR, |
| Bibliography | 1.Boggs I, Hine B, Smolenksi G, Hettinga K, Zhang L, Wheeler TT. Proteomics data in support of the quantification of the changes of bovine milk proteins during mammary gland involution. Data Brief. 2016 May 13;8:52-5. doi: 10.1016/j.dib.2016.05.013. PMID: 27274532; PMCID: PMC4885146. 2.Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005 Aug;3(8):1894-904. doi: 10.1111/j.1538-7836.2005.01365.x. PMID: 16102057. |