Primary Information
BoMiProt ID	Bomi5762
Protein Name	Ferritin light chain
Organism	Bos taurus
Uniprot ID	O46415
Milk Fraction	Exosomes
Ref Sequence ID	NP_777217.1
Aminoacid Length	175
Molecular Weight	19988
FASTA Sequence	Download
Gene Name	FTL
Gene ID	286861 and 788801
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	cortex of kidney
Protein Function	ferritin light chain (FTL), an important component of the iron storage protein ferritin.
Biochemical Properties	FTL has no enzymatic activity but accelerates the transfer of iron from the ferroxidase center to the iron core and stabilizes the ferritin complex structure
PTMs	N-acetylation at Ser
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|O46415|FRIL_BOVIN Ferritin light chain OS=Bos taurus OX=9913 GN=FTL PE=2 SV=3 MS*2SQIRQNYSTEVEAAVNRLVNMQLRASYTYLSLGFYFDRDDVALEGVGHFFRELAKEKR EGAERLLKLQNQRGGRALFLDVQKPSQDEWGKTQDAMEAALLVEKNLNQALLDLHGLASA RGDPHICDFLENHFLDEEVKLIKKMGDHLTNLRRLAGPQAGLGEYLFERLTLKHD
Predicted Disorder Regions	(1-5)
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	downregulation of FTL decreases the levels of PEN-2 and PS1 NTF.
Bibliography	1.Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW. Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neurosci Lett. 2013 Aug 26;548:90-4. doi: 10.1016/j.neulet.2013.05.018. Epub 2013 May 15. PMID: 23685131; PMCID: PMC3724929. 2.Ferritins: a family of molecules for iron storage, antioxidation and more.Arosio P, Ingrassia R, Cavadini P.Biochim Biophys Acta. 2009 Jul; 1790(7):589-99. 3.The iron redox and hydrolysis chemistry of the ferritins.Bou-Abdallah F.Biochim Biophys Acta. 2010 Aug; 1800(8):719-31.