Primary Information
BoMiProt ID	Bomi5733
Protein Name	F-box/LRR-repeat protein 4/F-box and leucine-rich repeat protein 4
Organism	Bos taurus
Uniprot ID	Q0VD31
Milk Fraction	Whey
Ref Sequence ID	NP_001069527.1
Aminoacid Length	621
Molecular Weight	70295
FASTA Sequence	Download
Gene Name	FBXL4
Gene ID	535452
Protein Existence Status	reviewed
Secondary Information
Protein Function	FBXL7, encodes a subcellular protein involved in phosphorylation-dependent ubiquitination processes and displays proapoptotic activity. F-box proteins also modulate inflammation and innate immunity, which may be important in late-onset Alzheimer's disease (LOAD) pathogenesis.
Biochemical Properties	F-box/LRR-repeat protein 2 (FBXL2), a component of Skp-Cullin-F box (SCF) ubiquitin E3 ligase, has been shown to inhibit tumorigenesis by targeting and ubiquitinating several oncoproteins.
PTMs	Methylation,SUMOylation and deSUMOylation,Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	no TM helices
Significance of PTMs	SUMOylation and deSUMOylation, was implicated in the regulation of FoxM1 transcriptional activity.FBXL2 is phosphorylated by GSK3b for the proper regulation in gastric cancer.
Additional Comments	Overexpression of FBXL2 inhibits, while its deficiency promotes cell proliferation and invasion.
Bibliography	1.Tosto G, Fu H, Vardarajan BN, Lee JH, Cheng R, Reyes-Dumeyer D, Lantigua R, Medrano M, Jimenez-Velazquez IZ, Elkind MS, Wright CB, Sacco RL, Pericak-Vance M, Farrer L, Rogaeva E, St George-Hyslop P, Reitz C, Mayeux R. F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease. Ann Clin Transl Neurol. 2015 Aug;2(8):810-20. doi: 10.1002/acn3.223. Epub 2015 Jun 18. PMID: 26339675; PMCID: PMC4554442. 2.Li LQ, Pan D, Chen H, Zhang L, Xie WJ. F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1. FEBS Lett. 2016 Feb;590(4):445-52. doi: 10.1002/1873-3468.12071. Epub 2016 Feb 8. PMID: 26790640. 3.Wang CM, Liu R, Wang L, Nascimento L, Brennan VC and Yang WH (2014) SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR200 family and JNK1 in MCF7 human breast cancer cells. Int J Mol Sci 15, 10233–10251. 4.Song JG, Xie HH, Li N, Wu K, Qiu JG, Shen DM and Huang CJ (2015) SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1. Tumour Biol 36, 9865–9871.