Primary Information
BoMiProt ID	Bomi5725
Protein Name	F-box only protein 28
Organism	Bos taurus
Uniprot ID	Q2NL16
Milk Fraction	Whey
Ref Sequence ID	NP_001039890.1
Aminoacid Length	368
Molecular Weight	41096
FASTA Sequence	Download
Gene Name	FBXO28
Gene ID	537745
Protein Existence Status	Reviewed
Secondary Information
Protein Function	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q2NL16|FBX28_BOVIN F-box only protein 28 OS=Bos taurus OX=9913 GN=FBXO28 PE=2 SV=1 MAAASEERMAEEGGGGHGDGGSPSAIASTQRLPPPPPPQPPQPGSQAPPAPALAPDQLPQ NNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQV KAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRV LRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGS*235PPVPG PS*242AALTTMQLFSKQNPSRQEVTKLQQQVKT*270NGAGVTVLRREISELRTKVQEQQKQLQDQD QKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQSEES*344PRKRKKAAEAIDSLRK SKRLRNRK
Predicted Disorder Regions	1-61, 125-135, 224-368
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Cdk1-dependent phosphorylation of Fbxo28 is required for efficient ubiquitylation but not degradation of c-MYC by stimulating c-MYC-p300 interactions at target promoters.
Bibliography	1.Kratz, A. S., Richter, K. T., Schlosser, Y. T., Schmitt, M., Shumilov, A., Delecluse, H. J., & Hoffmann, I. (2016). Fbxo28 promotes mitotic progression and regulates topoisomerase IIα-dependent DNA decatenation. Cell cycle (Georgetown, Tex.), 15(24), 3419–3431. https://doi.org/10.1080/15384101.2016.1246093 2.Yu, T., Wang, L., Zhao, C., Qian, B., Yao, C., He, F., Zhu, Y., Cai, M., Li, M., Zhao, D., Zhang, J., Wang, Y., & Qiu, W. (2019). Sublytic C5b-9 induces proliferation of glomerular mesangial cells via ERK5/MZF1/RGC-32 axis activated by FBXO28-TRAF6 complex. Journal of cellular and molecular medicine, 23(8), 5654–5671. https://doi.org/10.1111/jcmm.14473