Search by BoMiProt ID - Bomi5720

Primary Information

BoMiProt ID Bomi5720
Protein Name F-box and leucine-rich protein 22
Organism Bos taurus
Uniprot IDQ2HJF2
Milk FractionWhey
Ref Sequence ID NP_001039621.1
Aminoacid Length 226
Molecular Weight 25507
FASTA Sequence Download
Gene Name FBXL22
Gene ID 513821
Protein Existence Status reviewed

Secondary Information

Protein Function These are muscle-specific E3 ubiquitin ligases which is imp for skeletal muscle homeostasis and neurogenic muscle atrophy.Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as α-actinin and filamin C, and is essential for maintenance of normal contractile function.
Biochemical Properties Contains F motif which is located in its highly conserved N-terminal part and exhibiting an aggregation of numerous leucine residues (19% of all amino acids).
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Spaich S, Will RD, Just S, Spaich S, Kuhn C, Frank D, Berger IM, Wiemann S, Korn B, Koegl M, Backs J, Katus HA, Rottbauer W, Frey N. F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. Circ Res. 2012 Dec 7;111(12):1504-16. doi: 10.1161/CIRCRESAHA.112.271007. Epub 2012 Sep 12. PMID: 22972877.