Search by BoMiProt ID - Bomi5714

Primary Information

BoMiProt ID Bomi5714
Protein Name Fatty acyl-CoA reductase 2
Organism Bos taurus
Uniprot IDQ0P5J1
Milk FractionWhey
Ref Sequence ID NP_001069490.1
Aminoacid Length 515
Molecular Weight 59077
FASTA Sequence Download
Gene Name FAR2
Gene ID 534380
Protein Existence Status reviewed

Secondary Information

Protein Function Wax monoesters are synthesized via reduction of a fatty acid to a fatty alcohol, followed by transesterification of the fatty alcohol to a fatty acid. The first step is catalyzed by fatty acyl-CoA reductases (FARs), such as FAR2, using the reducing equivalents of NADPH to convert fatty acyl-CoA into a fatty alcohol and CoASH.Wax esters play essential roles in preventing water loss, abrasion, and infection.
Biochemical Properties Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols.Uses reducing equivalents of NADPH to convert fatty acyl-CoA into a fatty alcohol and CoASH.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 2TMHs; (466-484) and (491-509)
Additional Comments Both the FAR1 and FAR2 enzymes are localized to the peroxisome.The two FAR isozymes are ∼58% identical in sequence and are encoded by genes with similar exon-intron structures located on different chromosomes.
Bibliography Cheng JB, Russell DW. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem. 2004 Sep 3;279(36):37789-97. doi: 10.1074/jbc.M406225200. Epub 2004 Jun 27. PMID: 15220348; PMCID: PMC2757098.