Primary Information |
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| BoMiProt ID | Bomi5714 |
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| Protein Name | Fatty acyl-CoA reductase 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0P5J1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069490.1 |
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| Aminoacid Length | 515 |
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| Molecular Weight | 59077 |
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| FASTA Sequence |
Download |
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| Gene Name | FAR2 |
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| Gene ID | 534380 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Wax monoesters are synthesized via reduction of a fatty acid to a fatty alcohol, followed by transesterification of the fatty alcohol to a fatty acid. The first step is catalyzed by fatty acyl-CoA reductases (FARs), such as FAR2, using the reducing equivalents of NADPH to convert fatty acyl-CoA into a fatty alcohol and CoASH.Wax esters play essential roles in preventing water loss, abrasion, and infection. |
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| Biochemical Properties | Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols.Uses reducing equivalents of NADPH to convert fatty acyl-CoA into a fatty alcohol and CoASH. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (466-484) and (491-509) |
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| Additional Comments | Both the FAR1 and FAR2 enzymes are localized to the peroxisome.The two FAR isozymes are ∼58% identical in sequence and are encoded by genes with similar exon-intron structures located on different chromosomes. |
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| Bibliography | Cheng JB, Russell DW. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem. 2004 Sep 3;279(36):37789-97. doi: 10.1074/jbc.M406225200. Epub 2004 Jun 27. PMID: 15220348; PMCID: PMC2757098. |
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