Biochemical Properties | FADD is the key transducer of the apoptotic signal triggered by all death receptors of the TNF family, such as Fas, TNF receptor 1 (TNF-R1), death receptor 3 (DR3), TNF-related apoptosis-inducing ligand TRAIL-R1 (DR4) and TRAIL-R2 (DR5).FADD binds directly or indirectly to the intracellular domain of these receptors via its death domain (DD) and transduces the signal to pro-caspase-8 via a homotypic interaction of their respective DEDs. The binding of FADD to the death receptors and to pro-caspase-8 gives rise to the DISC. Consequently, pro-caspase-8 is cleaved into active caspase-8 that will in turn activate effector caspases like caspase-3 to induce apoptosis. |
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