Primary Information |
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| BoMiProt ID | Bomi5704 |
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| Protein Name | Farnesyl pyrophosphate synthase/Dimethylallyltranstransferase/Geranyltranstransferase |
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| Organism | Bos taurus |
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| Uniprot ID | Q8WMY2 |
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| Milk Fraction | Exosomes |
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| Aminoacid Length | 353 |
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| Molecular Weight | 40510 |
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| FASTA Sequence |
Download |
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| Gene Name | FDPS |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | This enzyme catalyzes the two-step synthesis of the C15 isoprenoid farnesyl pyrophosphate (FPP): isoprenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) are coupled to produce geranyl pyrophosphate (GPP), which is then condensed with an additional IPP to produce FPP. |
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| Biochemical Properties | FPPS belongs to the prenyltransferase group and FPPS proteins purified from different organisms have all proved to be homodimeric with subunit sizes from 32 to 44 kDa, typically displaying two aspartate-rich motifs with two substrate binding sites per monomer, one for an allylic diphosphate and one for IPP. |
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| PTMs | N6-acetylation at Lysine,Hydroxylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (201-219) |
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| Additional Comments | Overexpression of FPPS in fibroblasts also increases farnesylation of Ras signaling protein and activates the extracellular Ras/ERK signaling cascade. |
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| Bibliography | 1.Sun S, McKenna CE. Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). Expert Opin Ther Pat. 2011 Sep;21(9):1433-51. doi: 10.1517/13543776.2011.593511. Epub 2011 Jun 25. PMID: 21702715; PMCID: PMC3510766. 2. Ogura K, Koyama T. Enzymatic Aspects of Isoprenoid Chain Elongation. Chem Rev. 1998;98:1263–76. A comprehensive review of the structure and function of the isoprenyl pyrophosphate synthases which are used during isoprenoid chain elongation process. 3.Szkopinska A, Plochocka D. Farnesyl diphosphate synthase; regulation of product specificity. Acta Biochim Pol. 2005;52:45–55. 4.Reilly, J.F. et al. (2002) A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction. Biochem. J. 366, 501–510. |
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