Search by BoMiProt ID - Bomi5704


Primary Information

BoMiProt ID Bomi5704
Protein Name Farnesyl pyrophosphate synthase/Dimethylallyltranstransferase/Geranyltranstransferase
Organism Bos taurus
Uniprot IDQ8WMY2
Milk FractionExosomes
Aminoacid Length 353
Molecular Weight 40510
FASTA Sequence Download
Gene Name FDPS
Protein Existence Status Reviewed

Secondary Information

Protein Function  This enzyme catalyzes the two-step synthesis of the C15 isoprenoid farnesyl pyrophosphate (FPP): isoprenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) are coupled to produce geranyl pyrophosphate (GPP), which is then condensed with an additional IPP to produce FPP. 
Biochemical Properties FPPS belongs to the prenyltransferase group and FPPS proteins purified from different organisms have all proved to be homodimeric with subunit sizes from 32 to 44 kDa, typically displaying two aspartate-rich motifs with two substrate binding sites per monomer, one for an allylic diphosphate and one for IPP.
PTMs N6-acetylation at Lysine,Hydroxylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (201-219)
Additional Comments Overexpression of FPPS in fibroblasts also increases farnesylation of Ras signaling protein and activates the extracellular Ras/ERK signaling cascade.
Bibliography 1.Sun S, McKenna CE. Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). Expert Opin Ther Pat. 2011 Sep;21(9):1433-51. doi: 10.1517/13543776.2011.593511. Epub 2011 Jun 25. PMID: 21702715; PMCID: PMC3510766. 2. Ogura K, Koyama T. Enzymatic Aspects of Isoprenoid Chain Elongation. Chem Rev. 1998;98:1263–76. A comprehensive review of the structure and function of the isoprenyl pyrophosphate synthases which are used during isoprenoid chain elongation process. 3.Szkopinska A, Plochocka D. Farnesyl diphosphate synthase; regulation of product specificity. Acta Biochim Pol. 2005;52:45–55. 4.Reilly, J.F. et al. (2002) A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction. Biochem. J. 366, 501–510.