Primary Information |
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| BoMiProt ID | Bomi5654 |
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| Protein Name | Extracellular calcium-sensing receptor/Parathyroid cell calcium-sensing receptor |
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| Organism | Bos taurus |
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| Uniprot ID | P35384 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776427.1 |
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| Aminoacid Length | 1085 |
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| Molecular Weight | 121171 |
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| FASTA Sequence |
Download |
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| Gene Name | CASR/GPRC2A/PCAR1 |
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| Gene ID | 281038 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The calcium-sensing receptor has a key role in calcium homeostasis, it is involved in the regulation of the serum calcium level within minutes via the secretion and action of parathyroid and the excretion of calcium in the kidney in a negative feedback manner. |
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| Biochemical Properties | The dimeric cell surface CaSR, in turn, links to various heterotrimeric and small molecular weight G proteins to regulate intracellular second messengers, lipid kinases, various protein kinases, and transcription factors that are part of the machinery enabling the receptor to modulate the functions of the wide variety of cells in which it is expressed. CaSR signaling is impacted by its interactions with several binding partners in addition to signaling elements per se (i.e., G proteins), including filamin-A and caveolin-1. |
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| PTMs | Disulfide bond formation, Glycosylation at Asn,Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P35384|CASR_BOVIN Extracellular calcium-sensing receptor OS=Bos taurus OX=9913 GN=CASR PE=2 SV=1
MALYSCCWILLAFSTWCTSAYGPDQRAQKKGDIILGGLFPIHFGVAVKDQDLKSRPESVE
CIRYNFRGFRWLQAMIFAIEEINSSPALLPN*91MTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDEFCN*131CSEHIPSTIAVVGATGSGISTAVANLLGLFYIPQVSYASSSRLLSNKNQ
FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDF
SELISQYSDEEKIQQVVEVIQN*262STAKVIVVFSSGPDLEPLIKEIVRRN*288ITGRIWLASEAW
ASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCH
LQEGAKGPLPVDTFLRGHEEGGARLSNSPTAFRPLCTGEEN*401ISSVETPYMDYTHLRISYN
VYLAVYSIAHALQDIYTCIPGRGLFTN*447GSCADIKKVEAWQVLKHLRHLN*469FTSNMGEQVTF
DECGDLAGN*489YSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINDEKILWSGFSREVPF
SN*542CSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACDKCPDDFWSNEN*595HTSCI
AKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLL
CCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWW
GLNLQFLLVFLCTFMQIVICAIWLNTAPPSSYRNHELEDEIIFITCHEGSLMALGFLIGY
TCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVI
AILAASFGLLACIFFNKVYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRQRS
SSLGGSTGSTPSSSISSKSNS*921EDPFPQQQPKRQKQPQPLALSPHNAQQPQPRPPSTPQPQ
PQSQQPPRCKQKVIFGSGTVTFSLSFDEPQKTAVAHRNSTHQTSLEAQKNNDALTKHQAL
LPLQCGETDSELTSQETGLQGPVGEDHQLEMEDPEEMSPALVVSNSRS*1068FVISGGGSTVTE
NMLRS |
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| Predicted Disorder Regions | 889-1085 |
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| DisProt Annotation | |
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| TM Helix Prediction | 7TMHs ; (616-638), (651-669),(684-706), (726-744), (771-793), (806-828), (840-862) |
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| Significance of PTMs | Ubiquitination is performed by RNF19A; which induces proteasomal degradation. |
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| Additional Comments | alcium-sensing receptor (CaSR), a widely expressed G-protein-coupled cell surface protein with an important function in bone mineral homeostasis. |
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| Bibliography | 1.Toka HR. New functional aspects of the extracellular calcium-sensing receptor. Curr Opin Nephrol Hypertens. 2014 Jul;23(4):352-60. doi: 10.1097/01.mnh.0000447016.21228.e0. PMID: 24867673; PMCID: PMC4190005. 2.Chakravarti B, Chattopadhyay N, Brown EM. Signaling through the extracellular calcium-sensing receptor (CaSR). Adv Exp Med Biol. 2012;740:103-42. doi: 10.1007/978-94-007-2888-2_5. PMID: 22453940. 3.Raue F, Haag C, Schulze E, Frank-Raue K. The role of the extracellular calcium-sensing receptor in health and disease. Exp Clin Endocrinol Diabetes. 2006 Sep;114(8):397-405. doi: 10.1055/s-2006-924315. PMID: 17039419. |
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