Primary Information |
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| BoMiProt ID | Bomi5648 |
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| Protein Name | Exportin-2/Chromosome segregation 1-like protein/Importin-alpha re-exporter |
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| Organism | Bos taurus |
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| Uniprot ID | A5D785 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001014933.2 |
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| Aminoacid Length | 971 |
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| Molecular Weight | 110375 |
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| FASTA Sequence |
Download |
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| Gene Name | CSE1L/XPO2 |
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| Gene ID | 518622 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | It is a key regulator of apoptosis, migration and invasion in colorectal cancer as it is associated with viability and apoptosis, cellular adhesion and invasion processes. |
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| Biochemical Properties | CSE1L functions as a nuclear transporter like proteins with a nuclear localization signal are transported into the nucleus by the importin-α/β complex. After translocation to the nucleus
the importin subunits are displaced and CSE1L binds
the free importin-α within the nucleus to mediate its
transport back to the cytoplasm thus explaining the subcellular localization of CSE1L to both the nuclear
and cytoplasmic compartments. |
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| PTMs | Acetylation and Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A5D785|XPO2_BOVIN Exportin-2 OS=Bos taurus OX=9913 GN=CSE1L PE=2 SV=1
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKV
CASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLS*112DAISIIGR
EDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF
ALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMN
NFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNL
LVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEE
AFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNP
SVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVL
KADGIKYITIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNSATL
FTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQ
KLLAVSKNPSKPHFNHYMFEAICLSIRITCKSNPAAVVNFEEALFLVFTEILQNDVQEFI
PYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIA
SAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQN
SKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK
ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQ
TAFSQLAFAGKKEHDPVGQMVNNPKIHLAQS*931LHKLSTACPGRVPSMVSTSLNAEALQYLQ
GYLQAASVTLL |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | CSE1L has been found to be over-expressed in several cancer types, including melanoma, lymphoid neoplasms, breast cancers, ovarian carcinomas and liver neoplasms |
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| Bibliography | 1.Alnabulsi A, Agouni A, Mitra S, Garcia-Murillas I, Carpenter B, Bird S, Murray GI. Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. J Pathol. 2012 Dec;228(4):471-81. doi: 10.1002/path.4031. Epub 2012 Aug 20. PMID: 22450763. 2.Brinkmann U, Brinkmann E, Gallo M, et al. Cloning and characterization of a cellular apoptosis susceptibility gene, the human
homologue to the yeast chromosome segregation gene CAS . Proc
Natl Acad Sci USA 1995; 92: 10427–10431. 3.Boni R, Wellmann A, Man YG, et al. Expression of the proliferation and apoptosis-associated CAS protein in benign and malignant
cutaneous melanocytic lesions. Am J Dermatopathol 1999; 21:
125–128. 4.Wellmann A, Krenacs L, Fest T, et al. Localization of the cell
proliferation and apoptosis-associated CAS protein in lymphoid
neoplasms. Am J Pathol 1997; 150: 25–30. 5.Peiro G, Diebold J, Baretton GB, et al. Cellular apoptosis susceptibility gene expression in endometrial carcinoma: correlation with
Bcl-2, Bax, and caspase-3 expression and outcome. Int J Gynecol
Pathol 2001; 20: 359–367. |
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