Primary Information |
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| BoMiProt ID | Bomi5643 |
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| Protein Name | Exonuclease V/Defects in morphology protein 1 homolog |
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| Organism | Bos taurus |
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| Uniprot ID | A2VDX7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075077.1 |
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| Aminoacid Length | 370 |
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| Molecular Weight | 41511 |
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| FASTA Sequence |
Download |
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| Gene Name | EXO5/DEM1 |
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| Gene ID | 538883 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | is involved in recombinational repair of double-strand breaks that are caused by defective DNA replication, DNA damaging agents and other factors. |
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| Biochemical Properties | heterotrimeric subunit structure and consists of 3 polypeptides,RecB, RecC and RecD.Is capable of unwinding DNA double helix by itsDNA helicase activity.Also contain nuclease activity,which is involved in the digestion of DNA.Binds 1 [4Fe-4S] cluster.Mg2+ in the catalytic centre. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-61, 360-370 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | Leung WY, Chung LH, Kava HW, Murray V. RecBCD (Exonuclease V) is inhibited by DNA adducts produced by cisplatin and ultraviolet light. Biochem Biophys Res Commun. 2018 Jan 1;495(1):666-671. doi: 10.1016/j.bbrc.2017.11.060. Epub 2017 Nov 10. PMID: 29129691. |
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