Primary Information |
|---|
| BoMiProt ID | Bomi5640 |
|---|
| Protein Name | Exocyst complex component 3-like protein |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q0VCR8 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001069350.1 |
|---|
| Aminoacid Length | 739 |
|---|
| Molecular Weight | 81295 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | EXOC3L1 |
|---|
| Gene ID | 526306 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | A component of exocyst protein,which is a octameric complex involved in docking or tethering of secretory vesicles to fusion sites of the plasma membrane.Also regulates insulin secretion, by translocating GLUT4 transporter. |
|---|
| Biochemical Properties | An isoform of Sec6 to regulate insulin secretion in pancreatic β cells.Serine-471 residue is surrounded by a consensus motif of a protein kinase Cζ (PKCζ) phosphorylation site. |
|---|
| PTMs | Phosphorylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | Researchers have found that overexpressed EXOC3L1 in Chinese hamster ovary cells significantly reduced cultured cell numbers. It also significantly increased apoptotic DNA ladder, caspase 3 activity, and cleavage of caspase 3 compared with the control. |
|---|
| Bibliography | 1.Matsumoto S, Okada J, Yamada E, Saito T, Okada K, Watanabe T, Nakajima Y, Ozawa A, Okada S, Yamada M. Overexpressed exocyst complex component 3-like 1 spontaneously induces apoptosis. Biomed Res. 2021;42(3):109-113. doi: 10.2220/biomedres.42.109. PMID: 34092752. |
|---|
