Primary Information |
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| BoMiProt ID | Bomi5618 |
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| Protein Name | Eukaryotic translation initiation factor 3 subunit D/Eukaryotic translation initiation factor 3 subunit 7/eIF-3-zeta |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T122 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029656.1 |
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| Aminoacid Length | 548 |
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| Molecular Weight | 63931 |
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| FASTA Sequence |
Download |
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| Gene Name | EIF3D |
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| Gene ID | 515226 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | spermatid |
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| Protein Function | Eukaryotic translation initiation factor 3 subunit D (eIF3D) normally regulates the growth of several types of human cancer cells. |
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| PTMs | N6-acetylation at Lysine,Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3T122|EIF3D_BOVIN Eukaryotic translation initiation factor 3 subunit D OS=Bos taurus OX=9913 GN=EIF3D PE=2 SV=1
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYS
SQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQ
TLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSS*161VEVRSDWEVKEEMDFPQLM
KMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAK
TQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQ
DEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRY
RRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAV
IATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQI
NLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFS*528S*529DEDDEEEEEEE
EEEEEEEA |
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| Predicted Disorder Regions | 17-20, 92-96, 122-160, 297-304, 524-548 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | eIF3D silencing might be a potential therapeutic strategy for leukemia. |
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| Bibliography | 1.Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan;438(1-2):191-198. doi: 10.1007/s11010-017-3127-5. Epub 2017 Aug 12. PMID: 28801778. |
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