Primary Information |
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| BoMiProt ID | Bomi5606 |
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| Protein Name | Eukaryotic initiation factor 4A-II/ATP-dependent RNA helicase eIF4A-2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SZ65 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029216.1 |
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| Aminoacid Length | 407 |
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| Molecular Weight | 46402 |
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| FASTA Sequence |
Download |
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| Gene Name | EIF4A2 |
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| Gene ID | 286819 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | cerebellum |
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| Protein Function | Eukaryotic initiation factor 4A-II (eIF4A2) is an ATP-dependent RNA helicase involved in mRNA translation. |
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| PTMs | Phosphorylation at Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3SZ65|IF4A2_BOVIN Eukaryotic initiation factor 4A-II OS=Bos taurus OX=9913 GN=EIF4A2 PE=2 SV=1
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQ
QRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKV
ILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGT*159PGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKE
ELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTV
SALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHR
IGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI |
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| Predicted Disorder Regions | (1-29) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Abnormal expression of eIF4A2 has been reported as a prognostic factor in different types of cancer. |
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| Bibliography | 1.Lyu S, Lu J, Chen W, Huang W, Huang H, Xi S, Yan S. High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncol Lett. 2020 Nov;20(5):177. doi: 10.3892/ol.2020.12038. Epub 2020 Aug 31. PMID: 32934744; PMCID: PMC7471732. |
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