Protein Function | DnaJ proteins, also known as heat shock protein 40
(Hsp40 or Hsc40) act as cochaperones to the molecular
chaperone DnaK (Hsp70), which is responsible for several
cellular processes such as rescuing misfolded proteins, folding
polypeptide chains, transport of polypeptides through membranes, assembly and disassembly of protein complexes, and
control of regulatory proteins; primarily facilitates the
hydrolysis of ATP from DnaK that is necessary for the
chaperone activity of DnaK; DNAJA1 appears to be involved in importing
proteins into the mitochondria |
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Bibliography | 1. Li, L., Sun, Y., Wu, J., Li, X., Luo, M., & Wang, G. (2015). The global effect of heat on gene expression in cultured bovine mammary epithelial cells. Cell Stress & Chaperones, 20(2), 381–389. https://doi.org/10.1007/s12192-014-0559-7. 2. Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., … Powers, R. (2014). Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry, 53(8), 1360–1372. https://doi.org/10.1021/bi401329a. |