Primary Information |
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| BoMiProt ID | Bomi5597 |
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| Protein Name | Essential MCU regulator, mitochondrial/Single-pass membrane protein with aspartate-rich tail 1, mitochondrial |
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| Organism | Bos taurus |
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| Uniprot ID | Q2M2S2 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001039402.1 |
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| Aminoacid Length | 107 |
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| Molecular Weight | 11450 |
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| FASTA Sequence |
Download |
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| Gene Name | SMDT1/EMRE |
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| Gene ID | 506149 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. |
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| Biochemical Properties | It is required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. |
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| PTMs | proteolytic degradation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-6, 27-29, 31-38, 99-107 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH ; (65-83) |
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| Significance of PTMs | Undergoes proteolytic degradation in neurons: degraded by AFG3L2 before SMDT1/EMRE assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU |
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| Bibliography | Xie, K. F., Guo, D. D., & Luo, X. J. (2019). SMDT1-driven change in mitochondrial dynamics mediate cell apoptosis in PDAC. Biochemical and biophysical research communications, 511(2), 323–329. https://doi.org/10.1016/j.bbrc.2019.02.043 |
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