Primary Information |
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| BoMiProt ID | Bomi5553 |
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| Protein Name | Equilibrative nucleoside transporter 3/Solute carrier family 29 member 3 |
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| Organism | Bos taurus |
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| Uniprot ID | A1A4N1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001073692.1 |
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| Aminoacid Length | 474 |
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| Molecular Weight | 51646 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC29A3/ENT3 |
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| Gene ID | 504503 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | nucleoside transporter protein.mediates influx and efflux of nucleosides across the membrane |
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| PTMs | Glycosylation on Asn, Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A1A4N1|S29A3_BOVIN Equilibrative nucleoside transporter 3 OS=Bos taurus OX=9913 GN=SLC29A3 PE=2 SV=1
MAIISEDDFRHTSNSTYRTAS*21SS*23LRADQEALLEKLLDRPPPSLQRPEDRFNGTYIIFFSL
GIGGLLPWNFFVTAQEYWIFKLSN*84CSSPAAGEEPKDSDILNYFESYLAVASTVPSVLCLA
LNFLLVNRVPIRVRVLASLTVMLAIFIVMTVLVKVDTSSWTHSFFTITITCMAILSGTST
IFNSSVFGMTGSFPMRNSQALISGGAMGGTLSAVASLVDLAVASDVTDSTLAFFLTADIF
LALCIGLYLLLPRLDYARYYMKPVWPTVFSGEEQLPQDSPSPTSVAPGSSDPQTPPLGPI
LKKTTGLGFCIIYLFFITSLIFPAICTNIESLSKGSGSPWSTKFFVPLTTFLLYNFADLC
GRQVTAWIQVPGPRSKALPGLALLRTCFVPLFVFCNYQPRGHLHTVLFQSDVYPVLFTSL
LGLSNGYLSTLALIYGPKIVPRELAEATGVVMTFYMGLGLVLGSACSALLVHLI |
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| Predicted Disorder Regions | (1-22), (32-44) , (271-292) |
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| DisProt Annotation | |
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| TM Helix Prediction | 11TMHs ; (54-72), (106-128), (135-153), (165-187), (200-218), (230-252), (305-327), (339-357), (377-395), (414-436) & (449-471) |
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| Additional Comments | mutations in this gene causees H syndrome, pigmented hypertrichosis with insulin dependent diabetes, Faisalabad histiocytosis, and dysosteosclerosis. |
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| Bibliography | Noavar S, Behroozi S, Tatarcheh T, Parvini F, Foroutan M, Fahimi H. A novel homozygous frame-shift mutation in the SLC29A3 gene: a new case report and review of literature. BMC Med Genet. 2019 Aug 29;20(1):147. doi: 10.1186/s12881-019-0879-7. PMID: 31464584; PMCID: PMC6716938. |
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