Primary Information
BoMiProt ID	Bomi5529
Protein Name	EP300-interacting inhibitor of differentiation 2/CREBBP/EP300 inhibitor 2/EID-1-like inhibitor of differentiation 2
Organism	Bos taurus
Uniprot ID	Q17QW4
Milk Fraction	Whey
Ref Sequence ID	NP_001071517.1
Aminoacid Length	219
Molecular Weight	23882
FASTA Sequence	Download
Gene Name	EID2
Gene ID	615269
Protein Existence Status	reviewed
Secondary Information
Protein Function	EID3 is a p300 acetyltransferase inhibitor which can directly regulate DNA methyltransferase 3A (DNMT3A) transdifferentiation into neural stem-like cells (uNSCL) in the umbilical cord mesenchymal stem cells (UMSC).Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation.Inhibits EP300 histone acetyltransferase activity.
PTMs	Methylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	1 disordered segment; (1-119)
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Methylation
Additional Comments	EID3 is considered as a potential methylation marker in colon cancer
Bibliography	Diao PY, Li SX, Peng J, Yang JH, Pan YC, Xu XP, Tang H, Hu JX, Zhao HF, Huang GD. Overexpression of EP300-interacting inhibitor of differentiation 3 predicts poor prognosis in patients with glioblastoma multiforme. Int J Clin Exp Pathol. 2020 May 1;13(5):979-988. PMID: 32509069; PMCID: PMC7270700.