Primary Information |
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BoMiProt ID | Bomi5503 |
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Protein Name | Endoribonuclease LACTB2/Beta-lactamase-like protein 2 |
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Organism | Bos taurus |
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Uniprot ID | Q1LZ83 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001069513.1 |
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Aminoacid Length | 288 |
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Molecular Weight | 32683 |
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FASTA Sequence |
Download |
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Gene Name | LACTB2 |
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Gene ID | 535021 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Display endoribonuclease activity on ssRNA with a preference for cleavage after purine-pyrimidine sequences.involved in the turnover of mitochondrial RNA, and is essential for mitochondrial function in human cells. |
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Biochemical Properties | Has no activity with double-stranded RNA or DNA.cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. Binds 2 Zn2+ ions per subunit. |
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Significance in milk | beta lactoglobulin synthesis |
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PTMs | Acetylation,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q1LZ83|LACB2_BOVIN Endoribonuclease LACTB2 OS=Bos taurus OX=9913 GN=LACTB2 PE=2 SV=1
MAATLQRIERLSSRVIRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPSIPEYISCLK
QALTEFNTAIQEIIVTHWHRDHTGGIGDICKSINNDTTYCVKKLPRNPERKEIIGNGEQQ
YVYVKDGDIIKTEGATLRVVYTPGHTDDHMALVLEEENALFSGDCILGEGTTVFEDLYDY
MNSLKELLKIKAKVIYPGHGPVIHNAEAKILQYISHRNIREQQILTVFHENFEKS*235FTAME
LVKSIYKDTPEHLHKMAQHNVLLHLKKLEKEGKIVSNTDPEKKWKAHL |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Levy S, Allerston CK, Liveanu V, Habib MR, Gileadi O, Schuster G. Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease. Nucleic Acids Res. 2016 Feb 29;44(4):1813-32. doi: 10.1093/nar/gkw050. Epub 2016 Jan 29. PMID: 26826708; PMCID: PMC4770246. |