Primary Information |
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| BoMiProt ID | Bomi5502 |
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| Protein Name | Endoribonuclease Dicer |
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| Organism | Bos taurus |
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| Uniprot ID | Q6TUI4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_976235.1 |
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| Aminoacid Length | 1923 |
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| Molecular Weight | 218258 |
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| FASTA Sequence |
Download |
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| Gene Name | DICER1 |
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| Gene ID | 337871 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Plays a crucial role in the biogenesis of small regulatory RNAs, such as microRNAs (miRNAs) and small interfering RNAs (siRNAs). |
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| Biochemical Properties | Dicer's endonuclease role extends beyond the generation of small RNAs; it is also involved in processing additional endogenous and exogenous substrates, and is becoming increasingly implicated in regulating a variety of other cellular processes, outside of its endonuclease function. |
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| PTMs | Phosphorylation of Dicer by ERK localizes it to the nucleus; it remains present during most of oogenesis but is rapidly lost from the terminal oocyte shortly before fertilization |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q6TUI4|DICER_BOVIN Endoribonuclease Dicer OS=Bos taurus OX=9913 GN=DICER1 PE=2 SV=3
MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNT
IVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLK
VGEYSNLEVSASWTKEKWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA
ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDL
VVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISK
QILSDCRAVLVVLGPWCADKVAGMMVRELQKHIKHEQEELHRKFLLFTDTFLRKIHALCE
EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWS*413DS*415EDDEE
DEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGEADTEPVVDDDDVFPPYVLRPEDGPRVTINTAIGHVNRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPRPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSS*1015AEKRK
AKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPVDFRYPNLDFGWKKSIDSKSFISIANSSSAENENYCKHSTIVVPENAAHQGANRTSPLENHDQMSVNCRTLFSES*1160PGKLQIEVSTDLTAINGLSYNKSLANGSYDLANRDFCQGN
HLNYYKQEIPVQPTTSYPIQNLYNYENQPKPSDECTLLSNKYLDGNANTSTSDGSPVTAA
VPGTTETGEAPPDRTASEQSPSPGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGD
SFLKHAITTVSLSALILDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVN
GLPPGYVVNQDKSNTEKWEKDEMTKDCMLANGKLDDDFEEEEEEEEDLMWRAHKEDADDE
DDFLEYDQEHIKFIDNMLMGS*1461GAFVKKIS*1469LS*14711PFSATDSAYEWKMPKKSSLGSLPFSSDFE
DFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSI
ADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKAMCPTRENFTSQQKNLSG
SRAAASGAGYRASVLKDLEYGCLKIPPRCMFDHPEADRTLRHLISGFENFEKKINYRFKN
KAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSAL
VNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKE
EDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLE
MEPEITKFS*1869PAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQV
PNS |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Dicer has also been found to participate in the chromosome fragmentation during apoptosis or in the inflammatory processes. |
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| Bibliography | 1.Koralewska N, Ciechanowska K, Pokornowska M, Figlerowicz M, Kurzyńska-Kokorniak A. Ludzka rybonukleaza Dicer – struktura i funkcje biologiczne [Human ribonuclease Dicer – structure and functions]. Postepy Biochem. 2019 Oct 1;65(3):173-182. Polish. doi: 10.18388/pb.2019_267. PMID: 31643164. 2.Song MS, Rossi JJ. Molecular mechanisms of Dicer: endonuclease and enzymatic activity. Biochem J. 2017 May 4;474(10):1603-1618. doi: 10.1042/BCJ20160759. PMID: 28473628; PMCID: PMC5415849. 3.Drake, M., Furuta, T., Suen, K.M., Gonzalez, G., Liu, B., Kalia, A. et al. (2014) A requirement for ERK-Dependent Dicer phosphorylation in coordinating
oocyte-to-Embryo transition in C. elegans. Dev. Cell 31, 614–628 doi:10.1016/j.devcel.2014.11.004. |
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