Primary Information
BoMiProt ID	Bomi55
Protein Name	Dehydrogenase/reductase SDR family member 9
Organism	Bos taurus
Uniprot ID	Q8HYR6
Milk Fraction	MFGM
Ref Sequence ID	NP_777158.1
Aminoacid Length	319
Molecular Weight	35388
FASTA Sequence	Download
Gene Name	DHRS9
Gene ID	282851
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	member of the short-chain dehydrogenase/reductase (SDR) superfamily; play an important role in various (patho)biochemical pathways including intermediary metabolism and biotransformation of xenobiotics. 3 alpha-Hydroxysteroid dehydrogenase (3 alpha HSD) is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone (DHT).
Biochemical Properties	integral protein of the endoplasmic reticulum,facing towards the lumen with a reducing activity toward several substrates bearing carbonyl groups, such as steroid hormones,xenobiotics and model substrates prerferably NADPH as the cofactor; mostly three transmembrane segments; hydrophobic middle and C-term predicted transmembrane segments might be part of the homodimer formation/interaction sites. 3 alpha HSD catalyzes the reversible reduction of DHT to 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha DIOL). The equilibrium of 3 alpha HSD reductive and oxidative activity is an important factor in the regulation of intracellular levels of DHT.
Significance in milk	oxidoreductase enzyme in milk
PTMs	No glycosylation motif
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Linking IDs
Bibliography	1. Hirokawa, T., Boon-Chieng, S., & Mitaku, S. (1998). SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics (Oxford, England), 14(4), 378–379. https://doi.org/10.1093/bioinformatics/14.4.378. 2. Stambergova, H., Skarydova, L., Dunford, J. E., & Wsol, V. (2014). Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. Chemico-Biological Interactions, 207, 52–57. https://doi.org/10.1016/j.cbi.2013.11.003. 3.Pirog EC, Collins DC. 3 Alpha-hydroxysteroid dehydrogenase activity in rat liver and skin. Steroids. 1994 Apr;59(4):259-64. doi: 10.1016/0039-128x(94)90110-4. PMID: 8079380.