Primary Information |
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| BoMiProt ID | Bomi5495 |
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| Protein Name | Endoplasmic reticulum aminopeptidase 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A6QPT7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069096.2 |
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| Aminoacid Length | 954 |
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| Molecular Weight | 109719 |
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| FASTA Sequence |
Download |
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| Gene Name | ERAP2 |
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| Gene ID | 513572 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) trims HLA class I-binding peptides, determining the peptide repertoire presented for immune recognition. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. hydrolyzes the basic residues Arg and Lys |
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| Biochemical Properties | Glycosylation on Asn |
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| PTMs | Disulfide bond, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QPT7|ERAP2_BOVIN Endoplasmic reticulum aminopeptidase 2 OS=Bos taurus OX=9913 GN=ERAP2 PE=2 SV=1
MANSCRKLIFNIYVVFYCSAVIMPQICICSQFTSSPIDQFNKDPKAFPVATNGEIFPWHE
LRLPTVVIPLHYDLLIHPN*79LTSLDFVASEKIEVLVRDATQFIILHSKDLEILN*113ASLQSEE
DVRYKKPGENLTVLSYPAHQQIALLVPEKLRAHLRYSVAIDFQAKLADGFEGFYKSTYRT
LGGETRTIAVTDFEPTEARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEG
GLLEDHFETTVRMSTYLVAYIVCDFTSVSGTASSGVKVSIYASPDKWSQTHYALEASVKL
LDFYENYFDIHYPLPKLDLVAIPDFASGAMENWGLITYRETSLLFDPKTSSTSDKLWVTK
VIAHELAHQWFGNLVTMEWWNDIWLNEGFARYMELISLN*399ITYPELQFDDSFSNTCFEVIK
RDSLNSSHPISNEAKTATQIKEMFDAVSYNKGACILNMLKDFLSEETFRKGIIHYLKKFT
YRNAKNDDLWHSLSNNCLEGDSTSGGFCYSDSRKTSNTLAFLRENVELKEMMATWTLQKG
IPLVVVKREGRSLRLQQERFLSGVFKEDPEWGTLQERYLWHIPVTYSTSSSQAIHRHILK
LKTDTVDLSEKTDWVKFNVDSSGYYIVHYEGQGWDELITLLNQN*644HTLLRPKDRLGLIHDA
FQLVSAGRLTLDKALDLTRYLQHETSIPALLKGLEYLELFYRMVERRNISDVTENLKHYL
LQYFKPVIDTQSWLDEGSVWDRMLRSTVLKLACYLNHAPCIQKATELFSQWMESSGKLNI
PADVLTIVYSVGAQTTAGWNYLLEQYELSLSGAEKNKILYALSTSKHQEKLMKLIELGME
GKVIKTQDLATLLFTTARNPKGQQLAWNFVKENWTHLLKKFELGSFPIRMIISGTTSHFS
SKDELQEVKLFFESLKAQGSHLDIFQIILETISKNIKWLEKNLPTLRKWLLTSI |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH;(13-35) |
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| Bibliography | Lee ED. Endoplasmic Reticulum Aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance? Placenta. 2017 Aug;56:40-43. doi: 10.1016/j.placenta.2017.03.012. Epub 2017 Mar 18. PMID: 28343731; PMCID: PMC5522626. |
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