Primary Information |
|---|
| BoMiProt ID | Bomi5487 |
|---|
| Protein Name | Endonuclease III-like protein 1/Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase/DNA glycosylase/AP lyase |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q2KID2 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001039862.1 |
|---|
| Aminoacid Length | 305 |
|---|
| Molecular Weight | 33645 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | NTHL1 |
|---|
| Gene ID | 535203 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | DNA glycosylase required for the repair of oxidized bases, such as thymine glycol, within the base excision repair pathway. |
|---|
| PTMs | ubl conjugation,Phosphorylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KID2|NTH_BOVIN Endonuclease III-like protein 1 OS=Bos taurus OX=9913 GN=NTHL1 PE=2 SV=1
MNAAGVRMVVTRARSRGTGASLRRRGEKAAPLRSGEAAAEERKSYSPVKRRRKAQRLSVA
YEAS*64EGEGGEGAEHLQAPSWQPQDWRQQLDNIRTMRSGKDAPVDQLGAEHCFDPSASPKV
RRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDSTLGALIYPVGFWRSKVK
YIKQTSAILQQRYDGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIAN
RLRWTKKATKSPEETRRALEEWLPRELWSEINGLLVGFGQQTCLPIRPRCQACLNRALCP
AARGL |
|---|
| Predicted Disorder Regions | 1-91, 100-109 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | E3 ubiquitin ligase tripartite motif 26 (TRIM26) is targeting NTH1 for polyubiquitylation on lysine 67 present within the N terminus of the protein in vitro. |
|---|
| Bibliography | Williams SC, Parsons JL. NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress. Mol Cell Biol. 2018 May 29;38(12):e00616-17. doi: 10.1128/MCB.00616-17. PMID: 29610152; PMCID: PMC5974432. |
|---|
