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Primary Information | |
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| BoMiProt ID | Bomi5463 |
| Protein Name | Elongin-C/Elongin 15 kDa subunit/RNA polymerase II transcription factor SIII subunit C/SIII p15/Transcription elongation factor B polypeptide 1 |
| Organism | Bos taurus |
| Uniprot ID | Q2KII4 |
| Milk Fraction | whey |
| Ref Sequence ID | NP_001039958.1 |
| Aminoacid Length | 112 |
| Molecular Weight | 12473 |
| FASTA Sequence | Download |
| Gene Name | ELOC/TCEB1 |
| Gene ID | 540859 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Important component of the Elongin (SIII) complex stimulates the rate of elongation by RNA polymerase II by suppressing transient pausing by polymerase at many sites along DNA templates. |
| Biochemical Properties | The Elongin (SIII) complex is composed of a transcriptionally active A subunit, a chaperone-like B subunit, which promotes assembly and enhances stability of the Elongin (SIII) complex, and a regulatory C subunit.Elongin C is capable of interacting directly with Elongin A in the absence of Elongin B to form an AC complex with increased specific activity, suggesting that Elongin C functions as a direct activator of Elongin A. |
| PTMs | Ubl conjugation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : Alpha and beta proteins (a+b) Fold : POZ domain-like Superfamily : POZ domain Family : BTB/POZ domain Domain Name : 6I7Q C:17-112 |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | (1-16) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome. |
| PDB ID | 6I7Q, |
| Bibliography | 1.Takagi Y, Conaway RC, Conaway JW. Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A. J Biol Chem. 1996 Oct 11;271(41):25562-8. doi: 10.1074/jbc.271.41.25562. PMID: 8810329. |