Search by BoMiProt ID - Bomi5463

Primary Information

BoMiProt ID Bomi5463
Protein Name Elongin-C/Elongin 15 kDa subunit/RNA polymerase II transcription factor SIII subunit C/SIII p15/Transcription elongation factor B polypeptide 1
Organism Bos taurus
Uniprot IDQ2KII4
Milk Fractionwhey
Ref Sequence ID NP_001039958.1
Aminoacid Length 112
Molecular Weight 12473
FASTA Sequence Download
Gene Name ELOC/TCEB1
Gene ID 540859
Protein Existence Status reviewed

Secondary Information

Protein Function Important component of the Elongin (SIII) complex stimulates the rate of elongation by RNA polymerase II by suppressing transient pausing by polymerase at many sites along DNA templates.
Biochemical Properties The Elongin (SIII) complex is composed of a transcriptionally active A subunit, a chaperone-like B subunit, which promotes assembly and enhances stability of the Elongin (SIII) complex, and a regulatory C subunit.Elongin C is capable of interacting directly with Elongin A in the absence of Elongin B to form an AC complex with increased specific activity, suggesting that Elongin C functions as a direct activator of Elongin A.
PTMs Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a+b)
Fold : POZ domain-like
Superfamily : POZ domain
Family : BTB/POZ domain
Domain Name : 6I7Q C:17-112

CATH Matched CATH superfamily
Predicted Disorder Regions (1-16)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome.
Bibliography 1.Takagi Y, Conaway RC, Conaway JW. Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A. J Biol Chem. 1996 Oct 11;271(41):25562-8. doi: 10.1074/jbc.271.41.25562. PMID: 8810329.